Fabrication and characterization of SIS/PLGA film impregnated with dexamethasone

Even though the steroid drug dexamethasone is an efficacious antiinflammatory drug, it is difficult to formulate in an injectable formulation because of its poorly water solubility. So, polymeric film containing dexamatasone was designed drug delivery system including small intestinal submucosa (SIS) and sustained release of the drug from the polymeric system. poly(D,L-lactide-co-glycolide)(PLGA) is used for polymeric film that has been widely used as carriers in controlled release delivery system due to its biodegradability and relatively good biocompatibility. Also, the release behavior of dexamethasone on film controlled by adding the additive such as SIS. SIS derived from the submucosa layer of porcine intestine has been widely used as biomaterial due to low immune response and biocompatibility. SIS/PLGA film were manufactured by the method of solvent and characterized by scanning election microscopy (SEM). In vitro release behavior measured by HPLC and the PLGA molecular weight according to degradation of PLGA analyzed by GPC and pH meter. In this study, the films containing natural materials such as SIS according to content showed zero-order release profile. It was confirmed that the release of dexamethasone form films could be easily controlled by adding SIS.