Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition

Pratik Mishra; Sambit Ray; Sayantan Sinha; Bhaskar Das; Md Imran Khan; Susant K. Behera; Soon Il Yun; Suraj K. Tripathy; Amrita Mishra

doi:10.1016/j.bej.2015.09.021

Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition

Pratik Mishra
, Sambit Ray
, Sayantan Sinha
, Bhaskar Das
, Md Imran Khan
, Susant K. Behera
, Soon Il Yun
, Suraj K. Tripathy
, Amrita Mishra^*

^*Corresponding author for this work

Department of Food Science and Technology

Kalinga Institute of Industrial Technology
IMGENEX India Pvt. Ltd.

Research output: Contribution to journal › Journal article › peer-review

109 Scopus citations

Abstract

In the present paper, a facile synthesis of gold nanoparticles is reported with leaf and stem extract of Hibiscus sabdariffa. Structural features of as synthesized nanoparticles are characterized by UV-vis spectroscopy, XRD, FTIR, and XPS. Morphology of the above synthesized gold nanoparticles is investigated by electron microscopy. The stability of the nanoparticles is studied in different concentrations of glucose which suggested their possible application under hyperglycemic condition. As synthesized nanoparticles has shown selective toxicity towards U87 glioblastoma multiforme cell line under normal and hyperglycemic condition, indicating their potential to be used in the development of value-added products in the biochemical industries. The possible mode of activity of the above nanoparticles has been studied by in vitro molecular techniques.

Original language	English
Pages (from-to)	264-272
Number of pages	9
Journal	Biochemical Engineering Journal
Volume	105
DOIs	https://doi.org/10.1016/j.bej.2015.09.021
State	Published - 2016.01.15

Keywords

Biomedical
Biosynthesis
Cytotoxicity
DNA
Nanoparticles
Optimisation

Quacquarelli Symonds(QS) Subject Topics

Environmental Sciences
Engineering - Chemical
Biological Sciences

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10.1016/j.bej.2015.09.021

Cite this

Mishra, P., Ray, S., Sinha, S., Das, B., Khan, M. I., Behera, S. K., Yun, S. I., Tripathy, S. K., & Mishra, A. (2016). Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition. Biochemical Engineering Journal, 105, 264-272. https://doi.org/10.1016/j.bej.2015.09.021

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title = "Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition",

abstract = "In the present paper, a facile synthesis of gold nanoparticles is reported with leaf and stem extract of Hibiscus sabdariffa. Structural features of as synthesized nanoparticles are characterized by UV-vis spectroscopy, XRD, FTIR, and XPS. Morphology of the above synthesized gold nanoparticles is investigated by electron microscopy. The stability of the nanoparticles is studied in different concentrations of glucose which suggested their possible application under hyperglycemic condition. As synthesized nanoparticles has shown selective toxicity towards U87 glioblastoma multiforme cell line under normal and hyperglycemic condition, indicating their potential to be used in the development of value-added products in the biochemical industries. The possible mode of activity of the above nanoparticles has been studied by in vitro molecular techniques.",

keywords = "Biomedical, Biosynthesis, Cytotoxicity, DNA, Nanoparticles, Optimisation",

author = "Pratik Mishra and Sambit Ray and Sayantan Sinha and Bhaskar Das and Khan, \{Md Imran\} and Behera, \{Susant K.\} and Yun, \{Soon Il\} and Tripathy, \{Suraj K.\} and Amrita Mishra",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2016",

month = jan,

day = "15",

doi = "10.1016/j.bej.2015.09.021",

language = "English",

volume = "105",

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Mishra, P, Ray, S, Sinha, S, Das, B, Khan, MI, Behera, SK, Yun, SI, Tripathy, SK & Mishra, A 2016, 'Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition', Biochemical Engineering Journal, vol. 105, pp. 264-272. https://doi.org/10.1016/j.bej.2015.09.021

Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition. / Mishra, Pratik; Ray, Sambit; Sinha, Sayantan et al.
In: Biochemical Engineering Journal, Vol. 105, 15.01.2016, p. 264-272.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition

AU - Mishra, Pratik

AU - Ray, Sambit

AU - Sinha, Sayantan

AU - Das, Bhaskar

AU - Khan, Md Imran

AU - Behera, Susant K.

AU - Yun, Soon Il

AU - Tripathy, Suraj K.

AU - Mishra, Amrita

PY - 2016/1/15

Y1 - 2016/1/15

N2 - In the present paper, a facile synthesis of gold nanoparticles is reported with leaf and stem extract of Hibiscus sabdariffa. Structural features of as synthesized nanoparticles are characterized by UV-vis spectroscopy, XRD, FTIR, and XPS. Morphology of the above synthesized gold nanoparticles is investigated by electron microscopy. The stability of the nanoparticles is studied in different concentrations of glucose which suggested their possible application under hyperglycemic condition. As synthesized nanoparticles has shown selective toxicity towards U87 glioblastoma multiforme cell line under normal and hyperglycemic condition, indicating their potential to be used in the development of value-added products in the biochemical industries. The possible mode of activity of the above nanoparticles has been studied by in vitro molecular techniques.

AB - In the present paper, a facile synthesis of gold nanoparticles is reported with leaf and stem extract of Hibiscus sabdariffa. Structural features of as synthesized nanoparticles are characterized by UV-vis spectroscopy, XRD, FTIR, and XPS. Morphology of the above synthesized gold nanoparticles is investigated by electron microscopy. The stability of the nanoparticles is studied in different concentrations of glucose which suggested their possible application under hyperglycemic condition. As synthesized nanoparticles has shown selective toxicity towards U87 glioblastoma multiforme cell line under normal and hyperglycemic condition, indicating their potential to be used in the development of value-added products in the biochemical industries. The possible mode of activity of the above nanoparticles has been studied by in vitro molecular techniques.

KW - Biomedical

KW - Biosynthesis

KW - Cytotoxicity

KW - DNA

KW - Nanoparticles

KW - Optimisation

UR - https://www.scopus.com/pages/publications/84943737653

U2 - 10.1016/j.bej.2015.09.021

DO - 10.1016/j.bej.2015.09.021

M3 - Journal article

AN - SCOPUS:84943737653

SN - 1369-703X

VL - 105

SP - 264

EP - 272

JO - Biochemical Engineering Journal

JF - Biochemical Engineering Journal

ER -

Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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