Abstract
A novel one-pot synthesis of unsymmetrical ureas, carbamates and thiocarbamates from Cbz-protected amines has been developed. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, isocyanates are generated in situ, which facilitate rapid reaction with amines, alcohols, and thiols to afford the corresponding ureas, carbamates and thiocarbamates in high yields.
| Original language | English |
|---|---|
| Pages (from-to) | 7345-7353 |
| Number of pages | 9 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 14 |
| Issue number | 30 |
| DOIs | |
| State | Published - 2016 |
Quacquarelli Symonds(QS) Subject Topics
- Engineering - Petroleum
- Chemistry
- Biological Sciences
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