Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate

Minh Thanh La; Hee Kwon Kim

doi:10.1016/j.tetlet.2018.04.002

Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate

Minh Thanh La
, Hee Kwon Kim^*

^*Corresponding author for this work

Department of Medicine

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

A practical method for the direct preparation of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine is described. The reaction was readily performed in the presence of a catalytic amount of boron trifluoride-diethyl etherate at room temperature. Using this reaction protocol, various carboxylic acids were converted to DPM esters with high yields. This method is highly effective for the protection of carboxylic acids and the synthesis of DPM esters, and offers a promising approach for facile esterification of a variety of carboxylic acids.

Original language	English
Pages (from-to)	1855-1859
Number of pages	5
Journal	Tetrahedron Letters
Volume	59
Issue number	19
DOIs	https://doi.org/10.1016/j.tetlet.2018.04.002
State	Published - 2018.05.9

Keywords

Carboxylic acid
Diphenylmethyl ester
Esterification
Protecting groups

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Pharmacy & Pharmacology
Chemistry
Biological Sciences

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10.1016/j.tetlet.2018.04.002

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title = "Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate",

abstract = "A practical method for the direct preparation of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine is described. The reaction was readily performed in the presence of a catalytic amount of boron trifluoride-diethyl etherate at room temperature. Using this reaction protocol, various carboxylic acids were converted to DPM esters with high yields. This method is highly effective for the protection of carboxylic acids and the synthesis of DPM esters, and offers a promising approach for facile esterification of a variety of carboxylic acids.",

keywords = "Carboxylic acid, Diphenylmethyl ester, Esterification, Protecting groups",

author = "La, \{Minh Thanh\} and Kim, \{Hee Kwon\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = may,

day = "9",

doi = "10.1016/j.tetlet.2018.04.002",

language = "English",

volume = "59",

pages = "1855--1859",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate

AU - La, Minh Thanh

AU - Kim, Hee Kwon

PY - 2018/5/9

Y1 - 2018/5/9

N2 - A practical method for the direct preparation of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine is described. The reaction was readily performed in the presence of a catalytic amount of boron trifluoride-diethyl etherate at room temperature. Using this reaction protocol, various carboxylic acids were converted to DPM esters with high yields. This method is highly effective for the protection of carboxylic acids and the synthesis of DPM esters, and offers a promising approach for facile esterification of a variety of carboxylic acids.

AB - A practical method for the direct preparation of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine is described. The reaction was readily performed in the presence of a catalytic amount of boron trifluoride-diethyl etherate at room temperature. Using this reaction protocol, various carboxylic acids were converted to DPM esters with high yields. This method is highly effective for the protection of carboxylic acids and the synthesis of DPM esters, and offers a promising approach for facile esterification of a variety of carboxylic acids.

KW - Carboxylic acid

KW - Diphenylmethyl ester

KW - Esterification

KW - Protecting groups

UR - https://www.scopus.com/pages/publications/85045022609

U2 - 10.1016/j.tetlet.2018.04.002

DO - 10.1016/j.tetlet.2018.04.002

M3 - Journal article

AN - SCOPUS:85045022609

SN - 0040-4039

VL - 59

SP - 1855

EP - 1859

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 19

ER -

Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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