Facile tin(ii)-catalyzed synthesis of N-heterocycles from dicarboxylic acids and arylamines

A novel efficient transformation reaction of dicarboxylic acids into N-aryl-substituted azacycles is described. In this synthetic procedure, both catalytic SnCl₂ and phenylsilane were used as crucial reagents for reaction of arylamines with dicarboxylic acids to produce the desired azacycles. Using this SnCl₂-catalyzed synthetic method, various N-aryl-substituted azacycles were successfully prepared from arylamines with dicarboxylic acids in high yield. This practical synthetic method using catalytic SnCl₂ can provide a useful approach for preparation of the desired azacycle products from many available dicarboxylic acid starting materials.