Abstract
A novel practical synthesis of N-aryl-substituted azacycles from arylhydrazines is described. In this method, target azacycles were prepared via reaction of arylhydrazines with cyclic ethers in the presence of both titanium(IV) chloride and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as key combined reagents. Using this synthetic protocol with titanium(IV) chloride and TBD, reaction of arylhydrazines with cyclic ethers successfully afforded various N-aryl-substituted azacycles in high yield. This facile synthetic method using arylhydrazines will be a promising guide for the synthesis of azacycles from arylhydrazines.
| Original language | English |
|---|---|
| Pages (from-to) | 777-783 |
| Number of pages | 7 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 43 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2022.06 |
Keywords
- arylhydrazines
- azacycles
- heterocycles
- Lewis acids
- titanium(IV) chloride
Quacquarelli Symonds(QS) Subject Topics
- Chemistry
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