Flavonoids from propolis inhibit DNA single strand breakage by the fenton reaction

Myung Suk Han; In Kyoung Lee; Young Sook Kim; Jin Tae Kim; Kwang Ryul Choe; Bong Sik Yun

doi:10.3839/jksabc.2010.078

Flavonoids from propolis inhibit DNA single strand breakage by the fenton reaction

Myung Suk Han
, In Kyoung Lee
, Young Sook Kim
, Jin Tae Kim
, Kwang Ryul Choe
, Bong Sik Yun^*

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University
Chungnam National University

Research output: Contribution to journal › Journal article › peer-review

14 Scopus citations

Abstract

Ten flavonoids were isolated from the ethanolic extract of propolis collected in the Yangpyeong of Korea. Their structures were elucidated by extensive spectroscopic methods and identified as pinostrobin, tectochrysin, pinobanksin 3-acetoxy-7-methyl ether, 7-methylkaempferol, pinobanksin acetate, pinobanksin 3-(2-methyl)butylate, alpinone, pinobanksin, pinocembrin, and chrysin. These compounds exhibited an inhibitory effect on DNA single strand breakage by the Fenton reaction. Several flavonoids exhibited moderate scavenging activity against 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical cations, while all flavonoids showed no activity against superoxide and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals.

Original language	English
Pages (from-to)	512-515
Number of pages	4
Journal	Journal of Applied Biological Chemistry
Volume	53
Issue number	4
DOIs	https://doi.org/10.3839/jksabc.2010.078
State	Published - 2010.08.31

Keywords

Fenton reaction
Flavonoids
Hydroxyl radical scavenging activity
Korean propolis

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Engineering - Chemical
Chemistry

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10.3839/jksabc.2010.078

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@article{5070c0033dbc4613908d006fa8c9c3d2,

title = "Flavonoids from propolis inhibit DNA single strand breakage by the fenton reaction",

abstract = "Ten flavonoids were isolated from the ethanolic extract of propolis collected in the Yangpyeong of Korea. Their structures were elucidated by extensive spectroscopic methods and identified as pinostrobin, tectochrysin, pinobanksin 3-acetoxy-7-methyl ether, 7-methylkaempferol, pinobanksin acetate, pinobanksin 3-(2-methyl)butylate, alpinone, pinobanksin, pinocembrin, and chrysin. These compounds exhibited an inhibitory effect on DNA single strand breakage by the Fenton reaction. Several flavonoids exhibited moderate scavenging activity against 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical cations, while all flavonoids showed no activity against superoxide and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals.",

keywords = "Fenton reaction, Flavonoids, Hydroxyl radical scavenging activity, Korean propolis",

author = "Han, \{Myung Suk\} and Lee, \{In Kyoung\} and Kim, \{Young Sook\} and Kim, \{Jin Tae\} and Choe, \{Kwang Ryul\} and Yun, \{Bong Sik\}",

year = "2010",

month = aug,

day = "31",

doi = "10.3839/jksabc.2010.078",

language = "English",

volume = "53",

pages = "512--515",

journal = "Journal of Applied Biological Chemistry",

issn = "1976-0442",

number = "4",

}

TY - JOUR

T1 - Flavonoids from propolis inhibit DNA single strand breakage by the fenton reaction

AU - Han, Myung Suk

AU - Lee, In Kyoung

AU - Kim, Young Sook

AU - Kim, Jin Tae

AU - Choe, Kwang Ryul

AU - Yun, Bong Sik

PY - 2010/8/31

Y1 - 2010/8/31

N2 - Ten flavonoids were isolated from the ethanolic extract of propolis collected in the Yangpyeong of Korea. Their structures were elucidated by extensive spectroscopic methods and identified as pinostrobin, tectochrysin, pinobanksin 3-acetoxy-7-methyl ether, 7-methylkaempferol, pinobanksin acetate, pinobanksin 3-(2-methyl)butylate, alpinone, pinobanksin, pinocembrin, and chrysin. These compounds exhibited an inhibitory effect on DNA single strand breakage by the Fenton reaction. Several flavonoids exhibited moderate scavenging activity against 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical cations, while all flavonoids showed no activity against superoxide and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals.

AB - Ten flavonoids were isolated from the ethanolic extract of propolis collected in the Yangpyeong of Korea. Their structures were elucidated by extensive spectroscopic methods and identified as pinostrobin, tectochrysin, pinobanksin 3-acetoxy-7-methyl ether, 7-methylkaempferol, pinobanksin acetate, pinobanksin 3-(2-methyl)butylate, alpinone, pinobanksin, pinocembrin, and chrysin. These compounds exhibited an inhibitory effect on DNA single strand breakage by the Fenton reaction. Several flavonoids exhibited moderate scavenging activity against 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical cations, while all flavonoids showed no activity against superoxide and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals.

KW - Fenton reaction

KW - Flavonoids

KW - Hydroxyl radical scavenging activity

KW - Korean propolis

UR - https://www.scopus.com/pages/publications/78049380738

U2 - 10.3839/jksabc.2010.078

DO - 10.3839/jksabc.2010.078

M3 - Journal article

AN - SCOPUS:78049380738

SN - 1976-0442

VL - 53

SP - 512

EP - 515

JO - Journal of Applied Biological Chemistry

JF - Journal of Applied Biological Chemistry

IS - 4

ER -

Flavonoids from propolis inhibit DNA single strand breakage by the fenton reaction

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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