Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats

Paulrayer Antonisamy; Muniyappan Dhanasekaran; Savarimuthu Ignacimuthu; Veeramuthu Duraipandiyan; Joseph Devadass Balthazar; Paul Agastian; Jong Hoon Kim

doi:10.1016/j.phymed.2014.02.010

Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats

Paulrayer Antonisamy
, Muniyappan Dhanasekaran
, Savarimuthu Ignacimuthu
, Veeramuthu Duraipandiyan
, Joseph Devadass Balthazar
, Paul Agastian
, Jong Hoon Kim^*

^*Corresponding author for this work

Department of Veterinary Medicine

Jeonbuk National University
Loyola College India
King Saud University

Research output: Contribution to journal › Journal article › peer-review

44 Scopus citations

Abstract

The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats. Administration of indomethacin exhibits extreme levels of ulcer index (UI) and myeloperoxidase (MPO) activity. Indomethacin down regulated PGE₂, anti-inflammatory cytokines (IL-4, IL-10) and pro-angiogenic factors (VEGF and EGF). The ECD pretreatment considerably increased the levels of PGE₂, anti-inflammatory cytokines and pro-angiogenic factors. The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor (l-NAME), which indicates the involvement of PGE₂ and NOS in ECD induced ulcer healing activity. These findings suggest that ECD exerts its antiulcer activity by reinforcement of defensive elements and diminishing the offensive elements.

Original language	English
Pages (from-to)	966-969
Number of pages	4
Journal	Phytomedicine
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.phymed.2014.02.010
State	Published - 2014.06.15

Keywords

Antiulcer
Epoxy clerodane diterpene
Gastric ulcer
Tinospora cordifolia
Ulcer index

Quacquarelli Symonds(QS) Subject Topics

Medicine
Pharmacy & Pharmacology

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10.1016/j.phymed.2014.02.010

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title = "Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats",

abstract = "The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats. Administration of indomethacin exhibits extreme levels of ulcer index (UI) and myeloperoxidase (MPO) activity. Indomethacin down regulated PGE2, anti-inflammatory cytokines (IL-4, IL-10) and pro-angiogenic factors (VEGF and EGF). The ECD pretreatment considerably increased the levels of PGE2, anti-inflammatory cytokines and pro-angiogenic factors. The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor (l-NAME), which indicates the involvement of PGE2 and NOS in ECD induced ulcer healing activity. These findings suggest that ECD exerts its antiulcer activity by reinforcement of defensive elements and diminishing the offensive elements.",

keywords = "Antiulcer, Epoxy clerodane diterpene, Gastric ulcer, Tinospora cordifolia, Ulcer index",

author = "Paulrayer Antonisamy and Muniyappan Dhanasekaran and Savarimuthu Ignacimuthu and Veeramuthu Duraipandiyan and Balthazar, \{Joseph Devadass\} and Paul Agastian and Kim, \{Jong Hoon\}",

year = "2014",

month = jun,

day = "15",

doi = "10.1016/j.phymed.2014.02.010",

language = "English",

volume = "21",

pages = "966--969",

journal = "Phytomedicine",

issn = "0944-7113",

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TY - JOUR

T1 - Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats

AU - Antonisamy, Paulrayer

AU - Dhanasekaran, Muniyappan

AU - Ignacimuthu, Savarimuthu

AU - Duraipandiyan, Veeramuthu

AU - Balthazar, Joseph Devadass

AU - Agastian, Paul

AU - Kim, Jong Hoon

PY - 2014/6/15

Y1 - 2014/6/15

N2 - The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats. Administration of indomethacin exhibits extreme levels of ulcer index (UI) and myeloperoxidase (MPO) activity. Indomethacin down regulated PGE2, anti-inflammatory cytokines (IL-4, IL-10) and pro-angiogenic factors (VEGF and EGF). The ECD pretreatment considerably increased the levels of PGE2, anti-inflammatory cytokines and pro-angiogenic factors. The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor (l-NAME), which indicates the involvement of PGE2 and NOS in ECD induced ulcer healing activity. These findings suggest that ECD exerts its antiulcer activity by reinforcement of defensive elements and diminishing the offensive elements.

AB - The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats. Administration of indomethacin exhibits extreme levels of ulcer index (UI) and myeloperoxidase (MPO) activity. Indomethacin down regulated PGE2, anti-inflammatory cytokines (IL-4, IL-10) and pro-angiogenic factors (VEGF and EGF). The ECD pretreatment considerably increased the levels of PGE2, anti-inflammatory cytokines and pro-angiogenic factors. The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor (l-NAME), which indicates the involvement of PGE2 and NOS in ECD induced ulcer healing activity. These findings suggest that ECD exerts its antiulcer activity by reinforcement of defensive elements and diminishing the offensive elements.

KW - Antiulcer

KW - Epoxy clerodane diterpene

KW - Gastric ulcer

KW - Tinospora cordifolia

KW - Ulcer index

UR - https://www.scopus.com/pages/publications/84901621724

U2 - 10.1016/j.phymed.2014.02.010

DO - 10.1016/j.phymed.2014.02.010

M3 - Journal article

C2 - 24680619

AN - SCOPUS:84901621724

SN - 0944-7113

VL - 21

SP - 966

EP - 969

JO - Phytomedicine

JF - Phytomedicine

IS - 7

ER -

Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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