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Green synthesis of gold nanoparticles and their enhanced synergistic antitumor activity using HepG2 and MCF7 cells and its antibacterial effects

  • Thangavelu Muthukumar
  • , Sudhakumari
  • , Balaji Sambandam
  • , Adithan Aravinthan
  • , Thotapalli Parvathaleswara Sastry*
  • , Jong Hoon Kim
  • *Corresponding author for this work
  • CSIR - Central Leather Research Institute
  • Jeonbuk National University
  • Loyola College India
  • Indian Institute of Technology Madras

Research output: Contribution to journalJournal articlepeer-review

Abstract

One pot green synthesize of gold nanoparticles (AuNPs) were achieved using the leaf extracts of Carica papaya (CP) and Catharanthus roseus (CR) and the combination of these two extracts (CPCRM). The synthesized AuNPs were characterized for their size, morphology, crystallinity and their effects on bacterial and cancer cell lines were investigated. The electron microscopy results showed that AuNPs were mostly spherical, however, triangle and hexagonal shaped morphologies were also observed. The infra-red spectroscopy and microscopies studies revealed that alkaloids, flavonoids and proteins were present along with AuNPs which are responsible for their stabilization, non-agglomeration and biologically active characteristics including antibacterial and anticancer activity. Among the AuNPs prepared in this study, CPCRM extract showed enhanced activity due to the synergistic effects of both plant extracts.

Original languageEnglish
Pages (from-to)384-391
Number of pages8
JournalProcess Biochemistry
Volume51
Issue number3
DOIs
StatePublished - 2016.03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Carica papaya
  • Catharanthus roseus and anticancer activity
  • Gold nanoparticle
  • Green synthesis

Quacquarelli Symonds(QS) Subject Topics

  • Engineering - Chemical
  • Biological Sciences

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