H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels

Dongwon Lee; Eunkyeong Jung; Lipjeong Jung

H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels

Dongwon Lee
, Eunkyeong Jung
, Lipjeong Jung

Department of Polymer -Nano Science &Technology

Jeonbuk National University

Research output: Contribution to conference › Conference paper › peer-review

Abstract

A thrombus (blood clot) forms in injured vessels with mainly activated platelets and fibrin to maintain the integrity of vasculature. However, obstruction of blood vessels by thrombosis slows blood flow, leading to death of tissues fed by the artery and is the main culprit of various life-threatening cardiovascular diseases. Platelet activation during thrombus formation is closely associated with a high level of hydrogen peroxide (H₂O₂), which mediates platelet-endothelium interactions and facilitates thrombotic events. Therefore, H₂O₂ holds great potential as a diagnostic and therapeutic target of thrombosed vessels. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and the significantly elevated level of H₂O₂, we developed H₂O₂-activatable novel nanomedicine (T-FBM) that could detect thrombi through the amplification of ultrasound/photoacoustic signal and serve as an antithrombotic nanomedicine.

Original language	English
Title of host publication	Society for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publication	The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Publisher	Society for Biomaterials
Pages	59
Number of pages	1
ISBN (Electronic)	9781510883901
State	Published - 2019
Event	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: 2019.04.3 → 2019.04.6

Publication series

Name	Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume	40
ISSN (Print)	1526-7547

Conference

Conference	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/Territory	United States
City	Seattle
Period	19.04.3 → 19.04.6

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Biological Sciences

Cite this

Lee, D., Jung, E., & Jung, L. (2019). H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 59). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Lee, Dongwon ; Jung, Eunkyeong ; Jung, Lipjeong. / H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. pp. 59 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

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title = "H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels",

abstract = "A thrombus (blood clot) forms in injured vessels with mainly activated platelets and fibrin to maintain the integrity of vasculature. However, obstruction of blood vessels by thrombosis slows blood flow, leading to death of tissues fed by the artery and is the main culprit of various life-threatening cardiovascular diseases. Platelet activation during thrombus formation is closely associated with a high level of hydrogen peroxide (H2O2), which mediates platelet-endothelium interactions and facilitates thrombotic events. Therefore, H2O2 holds great potential as a diagnostic and therapeutic target of thrombosed vessels. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and the significantly elevated level of H2O2, we developed H2O2-activatable novel nanomedicine (T-FBM) that could detect thrombi through the amplification of ultrasound/photoacoustic signal and serve as an antithrombotic nanomedicine.",

author = "Dongwon Lee and Eunkyeong Jung and Lipjeong Jung",

note = "Publisher Copyright: {\textcopyright} 2019 Omnipress - All rights reserved.; 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence ; Conference date: 03-04-2019 Through 06-04-2019",

year = "2019",

language = "English",

series = "Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium",

publisher = "Society for Biomaterials",

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Lee, D, Jung, E & Jung, L 2019, H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, pp. 59, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 19.04.3.

H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels. / Lee, Dongwon; Jung, Eunkyeong; Jung, Lipjeong.
Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. p. 59 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Contribution to conference › Conference paper › peer-review

TY - GEN

T1 - H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels

AU - Lee, Dongwon

AU - Jung, Eunkyeong

AU - Jung, Lipjeong

PY - 2019

Y1 - 2019

N2 - A thrombus (blood clot) forms in injured vessels with mainly activated platelets and fibrin to maintain the integrity of vasculature. However, obstruction of blood vessels by thrombosis slows blood flow, leading to death of tissues fed by the artery and is the main culprit of various life-threatening cardiovascular diseases. Platelet activation during thrombus formation is closely associated with a high level of hydrogen peroxide (H2O2), which mediates platelet-endothelium interactions and facilitates thrombotic events. Therefore, H2O2 holds great potential as a diagnostic and therapeutic target of thrombosed vessels. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and the significantly elevated level of H2O2, we developed H2O2-activatable novel nanomedicine (T-FBM) that could detect thrombi through the amplification of ultrasound/photoacoustic signal and serve as an antithrombotic nanomedicine.

AB - A thrombus (blood clot) forms in injured vessels with mainly activated platelets and fibrin to maintain the integrity of vasculature. However, obstruction of blood vessels by thrombosis slows blood flow, leading to death of tissues fed by the artery and is the main culprit of various life-threatening cardiovascular diseases. Platelet activation during thrombus formation is closely associated with a high level of hydrogen peroxide (H2O2), which mediates platelet-endothelium interactions and facilitates thrombotic events. Therefore, H2O2 holds great potential as a diagnostic and therapeutic target of thrombosed vessels. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and the significantly elevated level of H2O2, we developed H2O2-activatable novel nanomedicine (T-FBM) that could detect thrombi through the amplification of ultrasound/photoacoustic signal and serve as an antithrombotic nanomedicine.

UR - https://www.scopus.com/pages/publications/85065401666

M3 - Conference paper

AN - SCOPUS:85065401666

T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

SP - 59

BT - Society for Biomaterials Annual Meeting and Exposition 2019

PB - Society for Biomaterials

T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

Y2 - 3 April 2019 through 6 April 2019

ER -

Lee D, Jung E, Jung L. H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. p. 59. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

H2o2-activatable nanoparticles for contrast-enhanced photoacoustic imaging and therapy of thrombosed vessels

Abstract

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Conference

UN SDGs

Quacquarelli Symonds(QS) Subject Topics

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