High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging

Muhammad Rashed Javed; Supin Chen; Jack Lei; Jeffrey Collins; Maxim Sergeev; Hee Kwon Kim; Chang Jin Kim; R. Michael Van Dam; Pei Yuin Keng

doi:10.1039/c3cc47616b

High yield and high specific activity synthesis of [¹⁸F]fallypride in a batch microfluidic reactor for micro-PET imaging

Muhammad Rashed Javed
, Supin Chen
, Jack Lei
, Jeffrey Collins
, Maxim Sergeev
, Hee Kwon Kim
, Chang Jin Kim
, R. Michael Van Dam
, Pei Yuin Keng^*

^*Corresponding author for this work

Department of Medicine

University of California at Los Angeles

Research output: Contribution to journal › Journal article › peer-review

42 Scopus citations

Abstract

[¹⁸F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol⁻¹(20 Ci μmol⁻¹) (n = 4). Specific activity was ∼2-fold higher than [¹⁸F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

Original language	English
Pages (from-to)	1192-1194
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	10
DOIs	https://doi.org/10.1039/c3cc47616b
State	Published - 2014.01.2

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title = "High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging",

abstract = "[18F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6\% (n = 7) and an average specific activity of 730 GBq μmol−1(20 Ci μmol−1) (n = 4). Specific activity was ∼2-fold higher than [18F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.",

author = "Javed, \{Muhammad Rashed\} and Supin Chen and Jack Lei and Jeffrey Collins and Maxim Sergeev and Kim, \{Hee Kwon\} and Kim, \{Chang Jin\} and Dam, \{R. Michael Van\} and Keng, \{Pei Yuin\}",

year = "2014",

month = jan,

day = "2",

doi = "10.1039/c3cc47616b",

language = "English",

volume = "50",

pages = "1192--1194",

journal = "Chemical Communications",

issn = "1359-7345",

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TY - JOUR

T1 - High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging

AU - Javed, Muhammad Rashed

AU - Chen, Supin

AU - Lei, Jack

AU - Collins, Jeffrey

AU - Sergeev, Maxim

AU - Kim, Hee Kwon

AU - Kim, Chang Jin

AU - Dam, R. Michael Van

AU - Keng, Pei Yuin

PY - 2014/1/2

Y1 - 2014/1/2

N2 - [18F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol−1(20 Ci μmol−1) (n = 4). Specific activity was ∼2-fold higher than [18F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

AB - [18F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol−1(20 Ci μmol−1) (n = 4). Specific activity was ∼2-fold higher than [18F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

UR - https://www.scopus.com/pages/publications/84891689836

U2 - 10.1039/c3cc47616b

DO - 10.1039/c3cc47616b

M3 - Journal article

C2 - 24326303

AN - SCOPUS:84891689836

SN - 1359-7345

VL - 50

SP - 1192

EP - 1194

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

High yield and high specific activity synthesis of [¹⁸F]fallypride in a batch microfluidic reactor for micro-PET imaging

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