Human krüppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene

Jae Hyeon Yoon; Won Il Choi; Bu Nam Jeon; Dong In Koh; Min Kyeong Kim; Myung Hwa Kim; Jungho Kim; Sujin Susanne Hur; Kyung Sup Kim; Man Wook Hur

doi:10.1074/jbc.M113.526855

Human krüppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene

Jae Hyeon Yoon
, Won Il Choi
, Bu Nam Jeon
, Dong In Koh
, Min Kyeong Kim
, Myung Hwa Kim
, Jungho Kim
, Sujin Susanne Hur
, Kyung Sup Kim
, Man Wook Hur^*

^*Corresponding author for this work

Department of Medicine

Yonsei University
Sogang University

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

Background: HKR3, one of the POK family proteins, is uncharacterized in its biological function. Results: HKR3 activates transcription of ARF by interfering with FBI-1 binding on ARF promoter. Conclusion: HKR3 inhibits cell proliferation by activating transcription of ARF. Significance: HKR3 is a novel transcription activator of ARF, antagonizing proto oncogene FBI-1.

Original language	English
Pages (from-to)	4018-4031
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.526855
State	Published - 2014.02.14

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title = "Human kr{\"u}ppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene",

abstract = "Background: HKR3, one of the POK family proteins, is uncharacterized in its biological function. Results: HKR3 activates transcription of ARF by interfering with FBI-1 binding on ARF promoter. Conclusion: HKR3 inhibits cell proliferation by activating transcription of ARF. Significance: HKR3 is a novel transcription activator of ARF, antagonizing proto oncogene FBI-1.",

author = "Yoon, \{Jae Hyeon\} and Choi, \{Won Il\} and Jeon, \{Bu Nam\} and Koh, \{Dong In\} and Kim, \{Min Kyeong\} and Kim, \{Myung Hwa\} and Jungho Kim and Hur, \{Sujin Susanne\} and Kim, \{Kyung Sup\} and Hur, \{Man Wook\}",

year = "2014",

month = feb,

day = "14",

doi = "10.1074/jbc.M113.526855",

language = "English",

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journal = "Journal of Biological Chemistry",

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T1 - Human krüppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene

AU - Yoon, Jae Hyeon

AU - Choi, Won Il

AU - Jeon, Bu Nam

AU - Koh, Dong In

AU - Kim, Min Kyeong

AU - Kim, Myung Hwa

AU - Kim, Jungho

AU - Hur, Sujin Susanne

AU - Kim, Kyung Sup

AU - Hur, Man Wook

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: HKR3, one of the POK family proteins, is uncharacterized in its biological function. Results: HKR3 activates transcription of ARF by interfering with FBI-1 binding on ARF promoter. Conclusion: HKR3 inhibits cell proliferation by activating transcription of ARF. Significance: HKR3 is a novel transcription activator of ARF, antagonizing proto oncogene FBI-1.

AB - Background: HKR3, one of the POK family proteins, is uncharacterized in its biological function. Results: HKR3 activates transcription of ARF by interfering with FBI-1 binding on ARF promoter. Conclusion: HKR3 inhibits cell proliferation by activating transcription of ARF. Significance: HKR3 is a novel transcription activator of ARF, antagonizing proto oncogene FBI-1.

UR - https://www.scopus.com/pages/publications/84894109208

U2 - 10.1074/jbc.M113.526855

DO - 10.1074/jbc.M113.526855

M3 - Journal article

C2 - 24382891

AN - SCOPUS:84894109208

SN - 0021-9258

VL - 289

SP - 4018

EP - 4031

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

Human krüppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene

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