Hydroxyhibiscone a, a novel human neutrophil elastase inhibitor from Hibiscus syriacus

In Ja Ryoo; Bong Sik Yun; In Kyoung Lee; Young Hee Kim; Ik Soo Lee; Jong Seok Ahn; Ki Hwan Bae; Ick Dong Yoo

doi:10.4014/jmb.1004.04028

Hydroxyhibiscone a, a novel human neutrophil elastase inhibitor from Hibiscus syriacus

In Ja Ryoo
, Bong Sik Yun
, In Kyoung Lee
, Young Hee Kim
, Ik Soo Lee
, Jong Seok Ahn
, Ki Hwan Bae
, Ick Dong Yoo^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Research Institute of Bioscience and Biotechnology
Chungnam National University
Chungbuk National University

Research output: Contribution to journal › Journal article › peer-review

12 Scopus citations

Abstract

In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC₅₀ values of 5.2 and 4.6 μM, respectively.

Original language	English
Pages (from-to)	1189-1191
Number of pages	3
Journal	Journal of Microbiology and Biotechnology
Volume	20
Issue number	8
DOIs	https://doi.org/10.4014/jmb.1004.04028
State	Published - 2010.08

Keywords

Hibiscus syriacus
Human neutrophil elastase
Hydroxyhibiscone A

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10.4014/jmb.1004.04028

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title = "Hydroxyhibiscone a, a novel human neutrophil elastase inhibitor from Hibiscus syriacus",

abstract = "In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.",

keywords = "Hibiscus syriacus, Human neutrophil elastase, Hydroxyhibiscone A",

author = "Ryoo, \{In Ja\} and Yun, \{Bong Sik\} and Lee, \{In Kyoung\} and Kim, \{Young Hee\} and Lee, \{Ik Soo\} and Ahn, \{Jong Seok\} and Bae, \{Ki Hwan\} and Yoo, \{Ick Dong\}",

year = "2010",

month = aug,

doi = "10.4014/jmb.1004.04028",

language = "English",

volume = "20",

pages = "1189--1191",

journal = "Journal of Microbiology and Biotechnology",

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TY - JOUR

T1 - Hydroxyhibiscone a, a novel human neutrophil elastase inhibitor from Hibiscus syriacus

AU - Ryoo, In Ja

AU - Yun, Bong Sik

AU - Lee, In Kyoung

AU - Kim, Young Hee

AU - Lee, Ik Soo

AU - Ahn, Jong Seok

AU - Bae, Ki Hwan

AU - Yoo, Ick Dong

PY - 2010/8

Y1 - 2010/8

N2 - In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.

AB - In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.

KW - Hibiscus syriacus

KW - Human neutrophil elastase

KW - Hydroxyhibiscone A

UR - https://www.scopus.com/pages/publications/77957088109

U2 - 10.4014/jmb.1004.04028

DO - 10.4014/jmb.1004.04028

M3 - Journal article

C2 - 20798580

AN - SCOPUS:77957088109

SN - 1017-7825

VL - 20

SP - 1189

EP - 1191

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 8

ER -

Hydroxyhibiscone a, a novel human neutrophil elastase inhibitor from Hibiscus syriacus

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Keywords

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