Hypovascular hypointense nodules in hepatobiliary phase without T2 hyperintensity: long-term outcomes and added value of DWI in predicting hypervascular transformation

Hae Jin Yang; Ji Soo Song; Eun Jung Choi; Hye Mi Choi; Jae Do Yang; Woo Sung Moon

doi:10.1016/j.clinimag.2018.01.003

Hypovascular hypointense nodules in hepatobiliary phase without T2 hyperintensity: long-term outcomes and added value of DWI in predicting hypervascular transformation

Hae Jin Yang
, Ji Soo Song^*
, Eun Jung Choi
, Hye Mi Choi
, Jae Do Yang
, Woo Sung Moon

^*Corresponding author for this work

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

Purpose: To evaluate outcomes and risk factors associated with hypervascularization in hypovascular, hepatobiliary phase (HBP) hypointense nodules (HHNs) without T2 hyperintensity on gadoxetic acid-enhanced magnetic resonance (MR) images in chronic liver disease patients. Materials and methods: 222 HHNs were analyzed. Multivariate analysis with a Cox proportional hazard regression model was used. Results: 41 nodules became hypervascular hepatocellular carcinoma (HCC). History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were risk factors for hypervascularization (P <.05). Conclusion: History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were associated with nodular progression to hypervascular HCC.

Original language	English
Pages (from-to)	123-129
Number of pages	7
Journal	Clinical Imaging
Volume	50
DOIs	https://doi.org/10.1016/j.clinimag.2018.01.003
State	Published - 2018.07.1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diffusion weighted image
Gadoxetic acid
Hepatocellular carcinoma
Hypervascular transformation
Magnetic resonance imaging

Quacquarelli Symonds(QS) Subject Topics

Medicine

Access to Document

10.1016/j.clinimag.2018.01.003

Cite this

@article{41118a7059ec45c586bb8e2663cebecf,

title = "Hypovascular hypointense nodules in hepatobiliary phase without T2 hyperintensity: long-term outcomes and added value of DWI in predicting hypervascular transformation",

abstract = "Purpose: To evaluate outcomes and risk factors associated with hypervascularization in hypovascular, hepatobiliary phase (HBP) hypointense nodules (HHNs) without T2 hyperintensity on gadoxetic acid-enhanced magnetic resonance (MR) images in chronic liver disease patients. Materials and methods: 222 HHNs were analyzed. Multivariate analysis with a Cox proportional hazard regression model was used. Results: 41 nodules became hypervascular hepatocellular carcinoma (HCC). History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were risk factors for hypervascularization (P <.05). Conclusion: History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were associated with nodular progression to hypervascular HCC.",

keywords = "Diffusion weighted image, Gadoxetic acid, Hepatocellular carcinoma, Hypervascular transformation, Magnetic resonance imaging",

author = "Yang, \{Hae Jin\} and Song, \{Ji Soo\} and Choi, \{Eun Jung\} and Choi, \{Hye Mi\} and Yang, \{Jae Do\} and Moon, \{Woo Sung\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = jul,

day = "1",

doi = "10.1016/j.clinimag.2018.01.003",

language = "English",

volume = "50",

pages = "123--129",

journal = "Clinical Imaging",

issn = "0899-7071",

}

TY - JOUR

T1 - Hypovascular hypointense nodules in hepatobiliary phase without T2 hyperintensity

T2 - long-term outcomes and added value of DWI in predicting hypervascular transformation

AU - Yang, Hae Jin

AU - Song, Ji Soo

AU - Choi, Eun Jung

AU - Choi, Hye Mi

AU - Yang, Jae Do

AU - Moon, Woo Sung

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Purpose: To evaluate outcomes and risk factors associated with hypervascularization in hypovascular, hepatobiliary phase (HBP) hypointense nodules (HHNs) without T2 hyperintensity on gadoxetic acid-enhanced magnetic resonance (MR) images in chronic liver disease patients. Materials and methods: 222 HHNs were analyzed. Multivariate analysis with a Cox proportional hazard regression model was used. Results: 41 nodules became hypervascular hepatocellular carcinoma (HCC). History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were risk factors for hypervascularization (P <.05). Conclusion: History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were associated with nodular progression to hypervascular HCC.

AB - Purpose: To evaluate outcomes and risk factors associated with hypervascularization in hypovascular, hepatobiliary phase (HBP) hypointense nodules (HHNs) without T2 hyperintensity on gadoxetic acid-enhanced magnetic resonance (MR) images in chronic liver disease patients. Materials and methods: 222 HHNs were analyzed. Multivariate analysis with a Cox proportional hazard regression model was used. Results: 41 nodules became hypervascular hepatocellular carcinoma (HCC). History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were risk factors for hypervascularization (P <.05). Conclusion: History of HCC, hyperintensity on T1WI or DWI, and higher growth rate were associated with nodular progression to hypervascular HCC.

KW - Diffusion weighted image

KW - Gadoxetic acid

KW - Hepatocellular carcinoma

KW - Hypervascular transformation

KW - Magnetic resonance imaging

UR - https://www.scopus.com/pages/publications/85042930300

U2 - 10.1016/j.clinimag.2018.01.003

DO - 10.1016/j.clinimag.2018.01.003

M3 - Journal article

C2 - 29353716

AN - SCOPUS:85042930300

SN - 0899-7071

VL - 50

SP - 123

EP - 129

JO - Clinical Imaging

JF - Clinical Imaging

ER -

Hypovascular hypointense nodules in hepatobiliary phase without T2 hyperintensity: long-term outcomes and added value of DWI in predicting hypervascular transformation

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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