Immunomodulatory effects of the combination of Korean red ginseng and Cervi Parvum Cornu via the MAPK pathway

Bai Cheng Chen; Ajay Vijayakumar; Jun Hong Park; Chang Won Kang; Jong Hoon Kim

doi:10.1016/j.jgr.2025.08.010

Immunomodulatory effects of the combination of Korean red ginseng and Cervi Parvum Cornu via the MAPK pathway

Bai Cheng Chen
, Ajay Vijayakumar
, Jun Hong Park
, Chang Won Kang
, Jong Hoon Kim^*

^*Corresponding author for this work

Department of Veterinary Medicine

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

2 Scopus citations

Abstract

Korean red ginseng (KRG) and Cervi Parvum Cornu (CPC) act synergistically to improve cyclophosphamide-induced immunosuppression in rats, as evidenced by restoration of lymphocyte numbers, enhanced NK cell cytotoxic activity, normalization of NK cell-related cytokine profiles, and activation of the MAPK signaling pathway.

Original language	English
Pages (from-to)	776-780
Number of pages	5
Journal	Journal of Ginseng Research
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/j.jgr.2025.08.010
State	Published - 2025.11

Keywords

Cervi parvum cornu
Immunosuppression
Korean red ginseng
MAPK pathway
NK cell activity

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10.1016/j.jgr.2025.08.010

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title = "Immunomodulatory effects of the combination of Korean red ginseng and Cervi Parvum Cornu via the MAPK pathway",

abstract = "Korean red ginseng (KRG) and Cervi Parvum Cornu (CPC) act synergistically to improve cyclophosphamide-induced immunosuppression in rats, as evidenced by restoration of lymphocyte numbers, enhanced NK cell cytotoxic activity, normalization of NK cell-related cytokine profiles, and activation of the MAPK signaling pathway.",

keywords = "Cervi parvum cornu, Immunosuppression, Korean red ginseng, MAPK pathway, NK cell activity",

author = "Chen, \{Bai Cheng\} and Ajay Vijayakumar and Park, \{Jun Hong\} and Kang, \{Chang Won\} and Kim, \{Jong Hoon\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2025. Published by Elsevier B.V.",

year = "2025",

month = nov,

doi = "10.1016/j.jgr.2025.08.010",

language = "English",

volume = "49",

pages = "776--780",

journal = "Journal of Ginseng Research",

issn = "1226-8453",

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TY - JOUR

T1 - Immunomodulatory effects of the combination of Korean red ginseng and Cervi Parvum Cornu via the MAPK pathway

AU - Chen, Bai Cheng

AU - Vijayakumar, Ajay

AU - Park, Jun Hong

AU - Kang, Chang Won

AU - Kim, Jong Hoon

PY - 2025/11

Y1 - 2025/11

N2 - Korean red ginseng (KRG) and Cervi Parvum Cornu (CPC) act synergistically to improve cyclophosphamide-induced immunosuppression in rats, as evidenced by restoration of lymphocyte numbers, enhanced NK cell cytotoxic activity, normalization of NK cell-related cytokine profiles, and activation of the MAPK signaling pathway.

AB - Korean red ginseng (KRG) and Cervi Parvum Cornu (CPC) act synergistically to improve cyclophosphamide-induced immunosuppression in rats, as evidenced by restoration of lymphocyte numbers, enhanced NK cell cytotoxic activity, normalization of NK cell-related cytokine profiles, and activation of the MAPK signaling pathway.

KW - Cervi parvum cornu

KW - Immunosuppression

KW - Korean red ginseng

KW - MAPK pathway

KW - NK cell activity

UR - https://www.scopus.com/pages/publications/105017785072

U2 - 10.1016/j.jgr.2025.08.010

DO - 10.1016/j.jgr.2025.08.010

M3 - Journal article

AN - SCOPUS:105017785072

SN - 1226-8453

VL - 49

SP - 776

EP - 780

JO - Journal of Ginseng Research

JF - Journal of Ginseng Research

IS - 6

ER -

Immunomodulatory effects of the combination of Korean red ginseng and Cervi Parvum Cornu via the MAPK pathway

Abstract

Keywords

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