Improvement of dissolution property of pranlukast by nano-solid dispersion with poly(N-vinylpyrrolidone)

To overcome solubility of poorly water soluble drugs, we prepared solid dispersions containing nanopar-ticles of water insoluble pranlukast using spray dryer. These solid dispersions formulated to improve the dissolution of pranlukast. PVP-K30 used as a water soluble carrier for the solid dispersion and poloxamer used as a surfactant. Characterization of pranlukast solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and particle size analyzer. SEM and DSC were found that pranlukast is amorphous in solid dispersions. Particle size analyzer was used to investigate size of pranlukast in solid dispersions. The in vitro dissolution rate of pranlukast solid dispersion was significantly higher than the conventional drugs(Onon® and Pra-kanon®), as 11-33 folds. This studies illustrated the potential use of solid dispersion for the delivery of poorly water soluble drug, such as pranlukast by the oral route.