Improvement of pranlukast dissolution by nano solid dispersion

The aim of this study is to overcome solubility of poorly water soluble drugs. We prepared solid dispersion containing nanoparticle of improvement of dissolution property pranlukast by using spray dryer. This solid dispersions formulated to improvement of dissolution using eudragit® L100 as a water soluble for the solid dispersion using poloxamer as a surfactant. Characterization of pranlukast solid dispersion analyzed by particle size analyzer, DSC, XRD, TGA and FT-IR. particle size analyzer was used to investigate size of pranlukast in solid dispersions. DSC and XRD were used to analyze the amorphous of solid dispersions. TGA was used to analyzer the changed weight of pranlukast and solid dispersions. FT-IR was used to analyzer the salt formation by hydrogen bond between pranlukast and eudragit® L100. The in vitro test was carried out to find about improvement of dissolution rate of pranlukast solid dispersion in intestinal juice(pH 6.8), controlled experiment compared pranlukast solid disperion with conventional drugs(Onon®). This studies displayed improvement of dissolution of prepared solid dispersion by using spray drying, poorly water soluble of pranlukast as orally pharmaceutical formulation.