Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction

Soo Hwa Jang; Tae Hee Han; In Koo Hwang; Seon Ah Park; Yong Geun Kwak; Jin Bong Park; Seong Kyu Han; Pan Dong Ryu; So Yeong Lee

doi:10.1016/j.neulet.2010.08.030

Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction

Soo Hwa Jang
, Tae Hee Han
, In Koo Hwang
, Seon Ah Park
, Yong Geun Kwak
, Jin Bong Park
, Seong Kyu Han
, Pan Dong Ryu
, So Yeong Lee^*

^*Corresponding author for this work

Seoul National University
Jeonbuk National University
Chungnam National University

Research output: Contribution to journal › Journal article › peer-review

Abstract

The hypothalamus plays an important role in maintaining a homeostasis of the body against stress response. In particular, the paraventricular nucleus of the hypothalamus is a critical region for disorders related to the autonomic nervous system, such as congestive heart failure and hypertension αB-crystallin is a family of heat shock proteins that are widely expressed in the brain, including in glial cells, astrocytes, oligodendrocytes, and neurons. Many studies have demonstrated that expression level of αB-crystallin is up-regulated and involved in protecting cells from pathological conditions. In the present study, we examined the expression and potential role of αB-crystallin in the paraventricular nucleus (PVN) regions of rats with myocardial infarction (MI). Our results demonstrate that mRNA encoding αB-crystallin and protein for both native and phosphorylate forms (Ser-59) of αB-crystallin was significantly increased in the PVN during MI.

Original language	English
Pages (from-to)	123-127
Number of pages	5
Journal	Neuroscience Letters
Volume	484
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2010.08.030
State	Published - 2010.10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adaptation
Congestive heart failure
Heat shock protein

Quacquarelli Symonds(QS) Subject Topics

Medicine

Access to Document

10.1016/j.neulet.2010.08.030

Cite this

@article{7cee3a811a564a89b73f3c757ad9f27c,

title = "Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction",

abstract = "The hypothalamus plays an important role in maintaining a homeostasis of the body against stress response. In particular, the paraventricular nucleus of the hypothalamus is a critical region for disorders related to the autonomic nervous system, such as congestive heart failure and hypertension αB-crystallin is a family of heat shock proteins that are widely expressed in the brain, including in glial cells, astrocytes, oligodendrocytes, and neurons. Many studies have demonstrated that expression level of αB-crystallin is up-regulated and involved in protecting cells from pathological conditions. In the present study, we examined the expression and potential role of αB-crystallin in the paraventricular nucleus (PVN) regions of rats with myocardial infarction (MI). Our results demonstrate that mRNA encoding αB-crystallin and protein for both native and phosphorylate forms (Ser-59) of αB-crystallin was significantly increased in the PVN during MI.",

keywords = "Adaptation, Congestive heart failure, Heat shock protein",

author = "Jang, \{Soo Hwa\} and Han, \{Tae Hee\} and Hwang, \{In Koo\} and Park, \{Seon Ah\} and Kwak, \{Yong Geun\} and Park, \{Jin Bong\} and Han, \{Seong Kyu\} and Ryu, \{Pan Dong\} and Lee, \{So Yeong\}",

year = "2010",

month = oct,

doi = "10.1016/j.neulet.2010.08.030",

language = "English",

volume = "484",

pages = "123--127",

journal = "Neuroscience Letters",

issn = "0304-3940",

number = "2",

}

TY - JOUR

T1 - Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction

AU - Jang, Soo Hwa

AU - Han, Tae Hee

AU - Hwang, In Koo

AU - Park, Seon Ah

AU - Kwak, Yong Geun

AU - Park, Jin Bong

AU - Han, Seong Kyu

AU - Ryu, Pan Dong

AU - Lee, So Yeong

PY - 2010/10

Y1 - 2010/10

N2 - The hypothalamus plays an important role in maintaining a homeostasis of the body against stress response. In particular, the paraventricular nucleus of the hypothalamus is a critical region for disorders related to the autonomic nervous system, such as congestive heart failure and hypertension αB-crystallin is a family of heat shock proteins that are widely expressed in the brain, including in glial cells, astrocytes, oligodendrocytes, and neurons. Many studies have demonstrated that expression level of αB-crystallin is up-regulated and involved in protecting cells from pathological conditions. In the present study, we examined the expression and potential role of αB-crystallin in the paraventricular nucleus (PVN) regions of rats with myocardial infarction (MI). Our results demonstrate that mRNA encoding αB-crystallin and protein for both native and phosphorylate forms (Ser-59) of αB-crystallin was significantly increased in the PVN during MI.

AB - The hypothalamus plays an important role in maintaining a homeostasis of the body against stress response. In particular, the paraventricular nucleus of the hypothalamus is a critical region for disorders related to the autonomic nervous system, such as congestive heart failure and hypertension αB-crystallin is a family of heat shock proteins that are widely expressed in the brain, including in glial cells, astrocytes, oligodendrocytes, and neurons. Many studies have demonstrated that expression level of αB-crystallin is up-regulated and involved in protecting cells from pathological conditions. In the present study, we examined the expression and potential role of αB-crystallin in the paraventricular nucleus (PVN) regions of rats with myocardial infarction (MI). Our results demonstrate that mRNA encoding αB-crystallin and protein for both native and phosphorylate forms (Ser-59) of αB-crystallin was significantly increased in the PVN during MI.

KW - Adaptation

KW - Congestive heart failure

KW - Heat shock protein

UR - https://www.scopus.com/pages/publications/77956874815

U2 - 10.1016/j.neulet.2010.08.030

DO - 10.1016/j.neulet.2010.08.030

M3 - Journal article

C2 - 20723582

AN - SCOPUS:77956874815

SN - 0304-3940

VL - 484

SP - 123

EP - 127

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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