Increased expression of MET and RON receptor tyrosine kinases in canine cutaneous melanotic tumor

Jae Ik Han; Dae Yong Kim; Ki Jeong Na

Increased expression of MET and RON receptor tyrosine kinases in canine cutaneous melanotic tumor

Jae Ik Han
, Dae Yong Kim
, Ki Jeong Na^*

^*Corresponding author for this work

Department of Veterinary Medicine

Chungbuk National University
Seoul National University

Research output: Contribution to journal › Journal article › peer-review

1 Scopus citations

Abstract

Aberrant translocation of β-catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.

Original language	English
Pages (from-to)	429-432
Number of pages	4
Journal	Journal of Veterinary Clinics
Volume	26
Issue number	5
State	Published - 2009

Keywords

Canine melanotic tumor
MET
RON
RTKs
Wnt/β-catenin signaling pathway

Cite this

@article{a4ec018ad5ac4a6583a3acbc9d84305c,

title = "Increased expression of MET and RON receptor tyrosine kinases in canine cutaneous melanotic tumor",

abstract = "Aberrant translocation of β-catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28\% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.",

keywords = "Canine melanotic tumor, MET, RON, RTKs, Wnt/β-catenin signaling pathway",

author = "Han, \{Jae Ik\} and Kim, \{Dae Yong\} and Na, \{Ki Jeong\}",

year = "2009",

language = "English",

volume = "26",

pages = "429--432",

journal = "Journal of Veterinary Clinics",

issn = "1598-298X",

number = "5",

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TY - JOUR

T1 - Increased expression of MET and RON receptor tyrosine kinases in canine cutaneous melanotic tumor

AU - Han, Jae Ik

AU - Kim, Dae Yong

AU - Na, Ki Jeong

PY - 2009

Y1 - 2009

N2 - Aberrant translocation of β-catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.

AB - Aberrant translocation of β-catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.

KW - Canine melanotic tumor

KW - MET

KW - RON

KW - RTKs

KW - Wnt/β-catenin signaling pathway

UR - https://www.scopus.com/pages/publications/77953791226

M3 - Journal article

AN - SCOPUS:77953791226

SN - 1598-298X

VL - 26

SP - 429

EP - 432

JO - Journal of Veterinary Clinics

JF - Journal of Veterinary Clinics

IS - 5

ER -

Increased expression of MET and RON receptor tyrosine kinases in canine cutaneous melanotic tumor

Abstract

Keywords

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