Inhibition of immediate type allergic reactions by the aqueous extract of Kum-Hwang-San

Hyungmin Kim; Hyeyoung Shin; Eunhee Lee; Jieun Lee; Jinah Jung; Nyeonhyoung An; Youngmi Lee; Daeki Kim; Tomoko Jippo; Yukihiko Kitamura

doi:10.1016/S0192-0561(98)00038-1

Inhibition of immediate type allergic reactions by the aqueous extract of Kum-Hwang-San

Hyungmin Kim^*
, Hyeyoung Shin
, Eunhee Lee
, Jieun Lee
, Jinah Jung
, Nyeonhyoung An
, Youngmi Lee
, Daeki Kim
, Tomoko Jippo
, Yukihiko Kitamura

^*Corresponding author for this work

Department of Medicine

Wonkwang University
The University of Osaka

Research output: Contribution to journal › Journal article › peer-review

Abstract

We studied the effect of aqueous extract of Kum-Hwang-San (KHS) on mast cell-mediated immediate type allergic reactions. KHS (1-100 μg/site) inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80 (200 μg/site) in mice by both topical and intradermal application. KHS (0.1-100 μg/site) inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. KHS also inhibited concentration-dependently the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 and anti-DNP IgE. Moreover, KHS had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) secretion from RPMC. These results indicate that KHS inhibits immediate type allergic reactions by inhibition of histamine release and TNF-α secretion from mast cells in vivo and in vitro.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	International Journal of Immunopharmacology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/S0192-0561(98)00038-1
State	Published - 1998.09.24

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10.1016/S0192-0561(98)00038-1

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@article{f4d2e1e7c96a416ba8d3ea38a8a04b1b,

title = "Inhibition of immediate type allergic reactions by the aqueous extract of Kum-Hwang-San",

abstract = "We studied the effect of aqueous extract of Kum-Hwang-San (KHS) on mast cell-mediated immediate type allergic reactions. KHS (1-100 μg/site) inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80 (200 μg/site) in mice by both topical and intradermal application. KHS (0.1-100 μg/site) inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. KHS also inhibited concentration-dependently the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 and anti-DNP IgE. Moreover, KHS had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) secretion from RPMC. These results indicate that KHS inhibits immediate type allergic reactions by inhibition of histamine release and TNF-α secretion from mast cells in vivo and in vitro.",

author = "Hyungmin Kim and Hyeyoung Shin and Eunhee Lee and Jieun Lee and Jinah Jung and Nyeonhyoung An and Youngmi Lee and Daeki Kim and Tomoko Jippo and Yukihiko Kitamura",

year = "1998",

month = sep,

day = "24",

doi = "10.1016/S0192-0561(98)00038-1",

language = "English",

volume = "20",

pages = "285--294",

journal = "International Journal of Immunopharmacology",

issn = "0192-0561",

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}

TY - JOUR

T1 - Inhibition of immediate type allergic reactions by the aqueous extract of Kum-Hwang-San

AU - Kim, Hyungmin

AU - Shin, Hyeyoung

AU - Lee, Eunhee

AU - Lee, Jieun

AU - Jung, Jinah

AU - An, Nyeonhyoung

AU - Lee, Youngmi

AU - Kim, Daeki

AU - Jippo, Tomoko

AU - Kitamura, Yukihiko

PY - 1998/9/24

Y1 - 1998/9/24

N2 - We studied the effect of aqueous extract of Kum-Hwang-San (KHS) on mast cell-mediated immediate type allergic reactions. KHS (1-100 μg/site) inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80 (200 μg/site) in mice by both topical and intradermal application. KHS (0.1-100 μg/site) inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. KHS also inhibited concentration-dependently the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 and anti-DNP IgE. Moreover, KHS had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) secretion from RPMC. These results indicate that KHS inhibits immediate type allergic reactions by inhibition of histamine release and TNF-α secretion from mast cells in vivo and in vitro.

AB - We studied the effect of aqueous extract of Kum-Hwang-San (KHS) on mast cell-mediated immediate type allergic reactions. KHS (1-100 μg/site) inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80 (200 μg/site) in mice by both topical and intradermal application. KHS (0.1-100 μg/site) inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. KHS also inhibited concentration-dependently the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 and anti-DNP IgE. Moreover, KHS had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) secretion from RPMC. These results indicate that KHS inhibits immediate type allergic reactions by inhibition of histamine release and TNF-α secretion from mast cells in vivo and in vitro.

UR - https://www.scopus.com/pages/publications/0031858359

U2 - 10.1016/S0192-0561(98)00038-1

DO - 10.1016/S0192-0561(98)00038-1

M3 - Journal article

C2 - 9754676

AN - SCOPUS:0031858359

SN - 0192-0561

VL - 20

SP - 285

EP - 294

JO - International Journal of Immunopharmacology

JF - International Journal of Immunopharmacology

IS - 6

ER -

Inhibition of immediate type allergic reactions by the aqueous extract of Kum-Hwang-San

Abstract

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