Inhibitory activities of pancreatic lipase and phosphodiesterase from Korean medicinal plant extracts

Yun Mi Lee; Young Sook Kim; Youngseop Lee; Junghyun Kim; Hang Sun; Joo Hwan Kim; Jin Sook Kim

doi:10.1002/ptr.3644

Inhibitory activities of pancreatic lipase and phosphodiesterase from Korean medicinal plant extracts

Yun Mi Lee
, Young Sook Kim
, Youngseop Lee
, Junghyun Kim
, Hang Sun
, Joo Hwan Kim
, Jin Sook Kim^*

^*Corresponding author for this work

Department of Dentistry

Korea Institute of Oriental Medicine
CAS - Kunming Institute of Botany
Gachon University

Research output: Contribution to journal › Journal article › peer-review

46 Scopus citations

Abstract

To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC₅₀ values of 29.6μg/mL and 33.3μg/mL, respectively) and only anti-PDE activity (IC ₅₀ values of 20.08μg/mL and 35.15μg/mL, respectively).

Original language	English
Pages (from-to)	778-782
Number of pages	5
Journal	Phytotherapy Research
Volume	26
Issue number	5
DOIs	https://doi.org/10.1002/ptr.3644
State	Published - 2012.05

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Korean medicinal plants
pancreatic lipase
phosphodiesterase
Sorbus commixta
Viscum album

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title = "Inhibitory activities of pancreatic lipase and phosphodiesterase from Korean medicinal plant extracts",

abstract = "To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6μg/mL and 33.3μg/mL, respectively) and only anti-PDE activity (IC 50 values of 20.08μg/mL and 35.15μg/mL, respectively).",

keywords = "Korean medicinal plants, pancreatic lipase, phosphodiesterase, Sorbus commixta, Viscum album",

author = "Lee, \{Yun Mi\} and Kim, \{Young Sook\} and Youngseop Lee and Junghyun Kim and Hang Sun and Kim, \{Joo Hwan\} and Kim, \{Jin Sook\}",

year = "2012",

month = may,

doi = "10.1002/ptr.3644",

language = "English",

volume = "26",

pages = "778--782",

journal = "Phytotherapy Research",

issn = "0951-418X",

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TY - JOUR

T1 - Inhibitory activities of pancreatic lipase and phosphodiesterase from Korean medicinal plant extracts

AU - Lee, Yun Mi

AU - Kim, Young Sook

AU - Lee, Youngseop

AU - Kim, Junghyun

AU - Sun, Hang

AU - Kim, Joo Hwan

AU - Kim, Jin Sook

PY - 2012/5

Y1 - 2012/5

N2 - To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6μg/mL and 33.3μg/mL, respectively) and only anti-PDE activity (IC 50 values of 20.08μg/mL and 35.15μg/mL, respectively).

AB - To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6μg/mL and 33.3μg/mL, respectively) and only anti-PDE activity (IC 50 values of 20.08μg/mL and 35.15μg/mL, respectively).

KW - Korean medicinal plants

KW - pancreatic lipase

KW - phosphodiesterase

KW - Sorbus commixta

KW - Viscum album

UR - https://www.scopus.com/pages/publications/84859890141

U2 - 10.1002/ptr.3644

DO - 10.1002/ptr.3644

M3 - Journal article

C2 - 22069182

AN - SCOPUS:84859890141

SN - 0951-418X

VL - 26

SP - 778

EP - 782

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 5

ER -

Inhibitory activities of pancreatic lipase and phosphodiesterase from Korean medicinal plant extracts

Abstract

UN SDGs

Keywords

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