Inhibitory components from Glycosmis stenocarpa on pepper mild mottle virus

Jang Hoon Kim; Ju Yeon Yoon; Sun Jung Kwon; In Sook Cho; Nguyen Manh Cuong; Seung Kook Choi; Young Ho Kim; Gug Seoun Choi

doi:10.4014/jmb.1607.07034

Inhibitory components from Glycosmis stenocarpa on pepper mild mottle virus

Jang Hoon Kim
, Ju Yeon Yoon
, Sun Jung Kwon
, In Sook Cho
, Nguyen Manh Cuong
, Seung Kook Choi
, Young Ho Kim^*
, Gug Seoun Choi

^*Corresponding author for this work

Department of Bioenvironmental Chemistry

United States Food and Drug Administration
Korea Atomic Energy Research Institute
Vietnamese Academy of Science and Technology
Chungnam National University

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.

Original language	English
Pages (from-to)	2138-2140
Number of pages	3
Journal	Journal of Microbiology and Biotechnology
Volume	26
Issue number	12
DOIs	https://doi.org/10.4014/jmb.1607.07034
State	Published - 2016.12

Keywords

Antiviral agent
Electron miscroscopy
Glycosmis stenocarpa
Isomahanine
Pepper mild mottle virus

Access to Document

10.4014/jmb.1607.07034

Cite this

@article{9a143fae5265451fbc8282f5cb3b0765,

title = "Inhibitory components from Glycosmis stenocarpa on pepper mild mottle virus",

abstract = "The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.",

keywords = "Antiviral agent, Electron miscroscopy, Glycosmis stenocarpa, Isomahanine, Pepper mild mottle virus",

author = "Kim, \{Jang Hoon\} and Yoon, \{Ju Yeon\} and Kwon, \{Sun Jung\} and Cho, \{In Sook\} and Cuong, \{Nguyen Manh\} and Choi, \{Seung Kook\} and Kim, \{Young Ho\} and Choi, \{Gug Seoun\}",

note = "Publisher Copyright: {\textcopyright} 2016 by The Korean Society for Microbiology and Biotechnology.",

year = "2016",

month = dec,

doi = "10.4014/jmb.1607.07034",

language = "English",

volume = "26",

pages = "2138--2140",

journal = "Journal of Microbiology and Biotechnology",

issn = "1017-7825",

number = "12",

}

TY - JOUR

T1 - Inhibitory components from Glycosmis stenocarpa on pepper mild mottle virus

AU - Kim, Jang Hoon

AU - Yoon, Ju Yeon

AU - Kwon, Sun Jung

AU - Cho, In Sook

AU - Cuong, Nguyen Manh

AU - Choi, Seung Kook

AU - Kim, Young Ho

AU - Choi, Gug Seoun

PY - 2016/12

Y1 - 2016/12

N2 - The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.

AB - The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.

KW - Antiviral agent

KW - Electron miscroscopy

KW - Glycosmis stenocarpa

KW - Isomahanine

KW - Pepper mild mottle virus

UR - https://www.scopus.com/pages/publications/85008227691

U2 - 10.4014/jmb.1607.07034

DO - 10.4014/jmb.1607.07034

M3 - Journal article

C2 - 27586528

AN - SCOPUS:85008227691

SN - 1017-7825

VL - 26

SP - 2138

EP - 2140

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

IS - 12

ER -

Inhibitory components from Glycosmis stenocarpa on pepper mild mottle virus

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this