Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine

H. M. Kim; N. H. An; B. H. Yi; H. J. Chae; H. R. Kim; S. J. Moon; J. J. Kim; Taeck Park Seung Taeck Park; S. H. Baek

doi:10.3109/08923970009016419

Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine

H. M. Kim^*
, N. H. An
, B. H. Yi
, H. J. Chae
, H. R. Kim
, S. J. Moon
, J. J. Kim
, Taeck Park Seung Taeck Park
, S. H. Baek

^*Corresponding author for this work

Wonkwang University

Research output: Contribution to journal › Journal article › peer-review

2 Scopus citations

Abstract

We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 μg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 μg/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.

Original language	English
Pages (from-to)	253-266
Number of pages	14
Journal	Immunopharmacology and Immunotoxicology
Volume	22
Issue number	2
DOIs	https://doi.org/10.3109/08923970009016419
State	Published - 2000

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title = "Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine",

abstract = "We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 μg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 μg/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.",

author = "Kim, \{H. M.\} and An, \{N. H.\} and Yi, \{B. H.\} and Chae, \{H. J.\} and Kim, \{H. R.\} and Moon, \{S. J.\} and Kim, \{J. J.\} and \{Seung Taeck Park\}, \{Taeck Park\} and Baek, \{S. H.\}",

year = "2000",

doi = "10.3109/08923970009016419",

language = "English",

volume = "22",

pages = "253--266",

journal = "Immunopharmacology and Immunotoxicology",

issn = "0892-3973",

number = "2",

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TY - JOUR

T1 - Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine

AU - Kim, H. M.

AU - An, N. H.

AU - Yi, B. H.

AU - Chae, H. J.

AU - Kim, H. R.

AU - Moon, S. J.

AU - Kim, J. J.

AU - Seung Taeck Park, Taeck Park

AU - Baek, S. H.

PY - 2000

Y1 - 2000

N2 - We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 μg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 μg/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.

AB - We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 μg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 μg/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.

UR - https://www.scopus.com/pages/publications/0033849250

U2 - 10.3109/08923970009016419

DO - 10.3109/08923970009016419

M3 - Journal article

C2 - 10952030

AN - SCOPUS:0033849250

SN - 0892-3973

VL - 22

SP - 253

EP - 266

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 2

ER -

Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine

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