Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

Hyung Min Kim; Joon Ho Lee; Jin Hee Won; Eun Jeung Park; Han Jung Chae; Hyung Ryong Kim; Cheorl Ho Kim; Seung Hwa Baek

doi:10.1002/ptr.749

Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

Hyung Min Kim^*
, Joon Ho Lee
, Jin Hee Won
, Eun Jeung Park
, Han Jung Chae
, Hyung Ryong Kim
, Cheorl Ho Kim
, Seung Hwa Baek

^*Corresponding author for this work

Wonkwang University
Dongguk University

Research output: Contribution to journal › Journal article › peer-review

38 Scopus citations

Abstract

Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.

Original language	English
Pages (from-to)	572-576
Number of pages	5
Journal	Phytotherapy Research
Volume	15
Issue number	7
DOIs	https://doi.org/10.1002/ptr.749
State	Published - 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Compositae
IgE
Immunization
Siegesbeckia glabrescens
U266 human IgE-bearing B cells

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10.1002/ptr.749

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@article{25d828505b4842f0a7b0e40e2868518e,

title = "Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens",

abstract = "Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.",

keywords = "Compositae, IgE, Immunization, Siegesbeckia glabrescens, U266 human IgE-bearing B cells",

author = "Kim, \{Hyung Min\} and Lee, \{Joon Ho\} and Won, \{Jin Hee\} and Park, \{Eun Jeung\} and Chae, \{Han Jung\} and Kim, \{Hyung Ryong\} and Kim, \{Cheorl Ho\} and Baek, \{Seung Hwa\}",

year = "2001",

doi = "10.1002/ptr.749",

language = "English",

volume = "15",

pages = "572--576",

journal = "Phytotherapy Research",

issn = "0951-418X",

number = "7",

}

TY - JOUR

T1 - Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

AU - Kim, Hyung Min

AU - Lee, Joon Ho

AU - Won, Jin Hee

AU - Park, Eun Jeung

AU - Chae, Han Jung

AU - Kim, Hyung Ryong

AU - Kim, Cheorl Ho

AU - Baek, Seung Hwa

PY - 2001

Y1 - 2001

N2 - Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.

AB - Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.

KW - Compositae

KW - IgE

KW - Immunization

KW - Siegesbeckia glabrescens

KW - U266 human IgE-bearing B cells

UR - https://www.scopus.com/pages/publications/0034766193

U2 - 10.1002/ptr.749

DO - 10.1002/ptr.749

M3 - Journal article

C2 - 11746835

AN - SCOPUS:0034766193

SN - 0951-418X

VL - 15

SP - 572

EP - 576

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 7

ER -

Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

Abstract

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Keywords

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