Interaction of fibroblast cell onto physicochemically treated PLGA surfaces

In order to improve the cell-compatability of poly(L-lactide-co-glycolide) (75:25 by mole ratio of lactide to glycolide, PLGA) surfaces, the physicochemical treatments have been demonstrated. Chemical treatments were 70% perchloric acid, 50% sulfuric acid and 0.5 N sodium hydroxide solution and physical methods were corona and plasma treatment. The water contact angle of surface treated PLGA decreased from 73°to 50-60°, i.e., increased hydrophilicity, due to the introduction of oxygen-containing functional group onto PLGA backbone by the measurement of an electron spectroscopy for chemical analysis. It could be observed that the adhesion and growth of fibroblast cell on physicochemically treated PLGA surfaces, especially perchloric acid treated PLGA surface, were more active than on the control. In conclusion, it seems that surface wettability as hydrophilicity of PLGA plays an important role in cell adhesion, spreading and growth.