Abstract
The quantification of hepatitis B virus (HBV) DNA is critical for the diagnosis and management of HBV infections. We evaluated the performance of the Aptima HBV Quant assay for quantitative HBV DNA analysis. The intra-assay coefficient of variation for this assay was 2.08% (mean 3.45 log IU/mL) and 1.10% (mean 5.23 log IU/mL). Linearity ranged from 1.03 to 8.20 log IU/mL. The limit of detection was estimated at 4.31 IU/mL, which corresponded to the 4.29 IU/mL claimed by the manufacturer. All 25 other viral infections were determined to be negative. Passing-Bablok regression analysis showed no significant deviations between Aptima HBV Quant assay and Abbott RealTime HBV assay. The Aptima HBV Quant assay demonstrated comparable performance to the Abbott assay.
| Original language | English |
|---|---|
| Pages (from-to) | 684-685 |
| Number of pages | 2 |
| Journal | Annals of Clinical and Laboratory Science |
| Volume | 52 |
| Issue number | 4 |
| State | Published - 2022.07 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Abbott RealTime HBV assay
- Analytical performance
- Aptima HBV Quant Assay
- DNA quantification
- hepatitis B
- transcription-mediated amplification
Quacquarelli Symonds(QS) Subject Topics
- Medicine
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