Localization of ubiquitin carboxyl-terminal hydrolase-L1 in cynomolgus monkey placentas

S. Sekiguchi; A. Takatori; T. Negishi; J. Kwon; T. Kokubo; Y. Ishii; S. Kyuwa; Y. Yoshikawa

doi:10.1016/j.placenta.2004.05.007

Localization of ubiquitin carboxyl-terminal hydrolase-L1 in cynomolgus monkey placentas

S. Sekiguchi^*
, A. Takatori
, T. Negishi
, J. Kwon
, T. Kokubo
, Y. Ishii
, S. Kyuwa
, Y. Yoshikawa

^*Corresponding author for this work

Department of Veterinary Medicine

The University of Tokyo
National Center of Neurology and Psychiatry Kodaira
Fujifilm Corporation

Research output: Contribution to journal › Journal article › peer-review

9 Scopus citations

Abstract

Ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1) is a restrictedly expressed enzyme in neural and reproductive tissues, and it is considered to have a significant role in reproduction. In the present study, we investigated the localization of UCH-L1 in placenta of cynomolgus monkeys ( Macaca fascicularis ). UCH-L1 protein was detected in cytotrophoblasts of chorionic plate and villi, and decidual cells of decidua basalis in cynomolgus monkey placenta, and the amount of UCH-L1 protein in whole placenta increased as pregnancy progressed. These results supported that UCH-L1 is necessary for placental and fetal development in primate placenta. This is the first report to demonstrate the presence of UCH-L1 in primate placenta, and the cynomolgus monkey may be a useful model for the study of the functions of the ubiquitin-proteasome system in human pregnancy.

Original language	English
Pages (from-to)	99-103
Number of pages	5
Journal	Placenta
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.placenta.2004.05.007
State	Published - 2005.01

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10.1016/j.placenta.2004.05.007

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title = "Localization of ubiquitin carboxyl-terminal hydrolase-L1 in cynomolgus monkey placentas",

abstract = "Ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1) is a restrictedly expressed enzyme in neural and reproductive tissues, and it is considered to have a significant role in reproduction. In the present study, we investigated the localization of UCH-L1 in placenta of cynomolgus monkeys ( Macaca fascicularis ). UCH-L1 protein was detected in cytotrophoblasts of chorionic plate and villi, and decidual cells of decidua basalis in cynomolgus monkey placenta, and the amount of UCH-L1 protein in whole placenta increased as pregnancy progressed. These results supported that UCH-L1 is necessary for placental and fetal development in primate placenta. This is the first report to demonstrate the presence of UCH-L1 in primate placenta, and the cynomolgus monkey may be a useful model for the study of the functions of the ubiquitin-proteasome system in human pregnancy.",

author = "S. Sekiguchi and A. Takatori and T. Negishi and J. Kwon and T. Kokubo and Y. Ishii and S. Kyuwa and Y. Yoshikawa",

year = "2005",

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doi = "10.1016/j.placenta.2004.05.007",

language = "English",

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T1 - Localization of ubiquitin carboxyl-terminal hydrolase-L1 in cynomolgus monkey placentas

AU - Sekiguchi, S.

AU - Takatori, A.

AU - Negishi, T.

AU - Kwon, J.

AU - Kokubo, T.

AU - Ishii, Y.

AU - Kyuwa, S.

AU - Yoshikawa, Y.

PY - 2005/1

Y1 - 2005/1

N2 - Ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1) is a restrictedly expressed enzyme in neural and reproductive tissues, and it is considered to have a significant role in reproduction. In the present study, we investigated the localization of UCH-L1 in placenta of cynomolgus monkeys ( Macaca fascicularis ). UCH-L1 protein was detected in cytotrophoblasts of chorionic plate and villi, and decidual cells of decidua basalis in cynomolgus monkey placenta, and the amount of UCH-L1 protein in whole placenta increased as pregnancy progressed. These results supported that UCH-L1 is necessary for placental and fetal development in primate placenta. This is the first report to demonstrate the presence of UCH-L1 in primate placenta, and the cynomolgus monkey may be a useful model for the study of the functions of the ubiquitin-proteasome system in human pregnancy.

AB - Ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1) is a restrictedly expressed enzyme in neural and reproductive tissues, and it is considered to have a significant role in reproduction. In the present study, we investigated the localization of UCH-L1 in placenta of cynomolgus monkeys ( Macaca fascicularis ). UCH-L1 protein was detected in cytotrophoblasts of chorionic plate and villi, and decidual cells of decidua basalis in cynomolgus monkey placenta, and the amount of UCH-L1 protein in whole placenta increased as pregnancy progressed. These results supported that UCH-L1 is necessary for placental and fetal development in primate placenta. This is the first report to demonstrate the presence of UCH-L1 in primate placenta, and the cynomolgus monkey may be a useful model for the study of the functions of the ubiquitin-proteasome system in human pregnancy.

UR - https://www.scopus.com/pages/publications/12344261439

U2 - 10.1016/j.placenta.2004.05.007

DO - 10.1016/j.placenta.2004.05.007

M3 - Journal article

C2 - 15664418

AN - SCOPUS:12344261439

SN - 0143-4004

VL - 26

SP - 99

EP - 103

JO - Placenta

JF - Placenta

IS - 1

ER -

Localization of ubiquitin carboxyl-terminal hydrolase-L1 in cynomolgus monkey placentas

Abstract

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