Lysosomal membrane proteins exposed to melanin in melanocyte B16F10

Seung Hyuck Bang; Dong Jun Park; Yang Hoon Kim; Jiho Min

doi:10.1007/s13530-016-0282-0

Lysosomal membrane proteins exposed to melanin in melanocyte B16F10

Seung Hyuck Bang
, Dong Jun Park
, Yang Hoon Kim
, Jiho Min^*

^*Corresponding author for this work

Division of Chemical Engineering

Research output: Contribution to journal › Journal article › peer-review

1 Scopus citations

Abstract

There have been studied on therapeutic of anticancer and antimicrobial using by effective proteins or peptides. In this study, we examined the lysosomal membrane protein extracted from lysosomes isolated from melanocyte treated by melanin with 100 ppm for 24 hours in order to find them reacted to targeting ability to melanin using by 2-dimensional electrophoresis (2DE). Consequently, we found 29 up-regulated (2.0 fold) and 23 down-regulated (2.0 fold) spots associated with melanin treatment. This result shown that lysosomal membrane proteins have function to react to treatment or decrease of melanin quantity through cellular activation of lysosomes.

Original language	English
Pages (from-to)	253-257
Number of pages	5
Journal	Toxicology and Environmental Health Sciences
Volume	8
Issue number	3
DOIs	https://doi.org/10.1007/s13530-016-0282-0
State	Published - 2016.09.1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

2-Dimensional electrophoresis
Lysosomal membrane proteins
Lysosome
Melanin
Melanocyte

Quacquarelli Symonds(QS) Subject Topics

Environmental Sciences
Pharmacy & Pharmacology

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10.1007/s13530-016-0282-0

Cite this

@article{3098756d2ebc490ab074a1a9510d4123,

title = "Lysosomal membrane proteins exposed to melanin in melanocyte B16F10",

abstract = "There have been studied on therapeutic of anticancer and antimicrobial using by effective proteins or peptides. In this study, we examined the lysosomal membrane protein extracted from lysosomes isolated from melanocyte treated by melanin with 100 ppm for 24 hours in order to find them reacted to targeting ability to melanin using by 2-dimensional electrophoresis (2DE). Consequently, we found 29 up-regulated (2.0 fold) and 23 down-regulated (2.0 fold) spots associated with melanin treatment. This result shown that lysosomal membrane proteins have function to react to treatment or decrease of melanin quantity through cellular activation of lysosomes.",

keywords = "2-Dimensional electrophoresis, Lysosomal membrane proteins, Lysosome, Melanin, Melanocyte",

author = "Bang, \{Seung Hyuck\} and Park, \{Dong Jun\} and Kim, \{Yang Hoon\} and Jiho Min",

note = "Publisher Copyright: {\textcopyright} 2016, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.",

year = "2016",

month = sep,

day = "1",

doi = "10.1007/s13530-016-0282-0",

language = "English",

volume = "8",

pages = "253--257",

journal = "Toxicology and Environmental Health Sciences",

issn = "2005-9752",

number = "3",

}

TY - JOUR

T1 - Lysosomal membrane proteins exposed to melanin in melanocyte B16F10

AU - Bang, Seung Hyuck

AU - Park, Dong Jun

AU - Kim, Yang Hoon

AU - Min, Jiho

PY - 2016/9/1

Y1 - 2016/9/1

N2 - There have been studied on therapeutic of anticancer and antimicrobial using by effective proteins or peptides. In this study, we examined the lysosomal membrane protein extracted from lysosomes isolated from melanocyte treated by melanin with 100 ppm for 24 hours in order to find them reacted to targeting ability to melanin using by 2-dimensional electrophoresis (2DE). Consequently, we found 29 up-regulated (2.0 fold) and 23 down-regulated (2.0 fold) spots associated with melanin treatment. This result shown that lysosomal membrane proteins have function to react to treatment or decrease of melanin quantity through cellular activation of lysosomes.

AB - There have been studied on therapeutic of anticancer and antimicrobial using by effective proteins or peptides. In this study, we examined the lysosomal membrane protein extracted from lysosomes isolated from melanocyte treated by melanin with 100 ppm for 24 hours in order to find them reacted to targeting ability to melanin using by 2-dimensional electrophoresis (2DE). Consequently, we found 29 up-regulated (2.0 fold) and 23 down-regulated (2.0 fold) spots associated with melanin treatment. This result shown that lysosomal membrane proteins have function to react to treatment or decrease of melanin quantity through cellular activation of lysosomes.

KW - 2-Dimensional electrophoresis

KW - Lysosomal membrane proteins

KW - Lysosome

KW - Melanin

KW - Melanocyte

UR - https://www.scopus.com/pages/publications/84991494365

U2 - 10.1007/s13530-016-0282-0

DO - 10.1007/s13530-016-0282-0

M3 - Journal article

AN - SCOPUS:84991494365

SN - 2005-9752

VL - 8

SP - 253

EP - 257

JO - Toxicology and Environmental Health Sciences

JF - Toxicology and Environmental Health Sciences

IS - 3

ER -

Lysosomal membrane proteins exposed to melanin in melanocyte B16F10

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

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