Management of severely aberrant permanent first molars in molar root–incisor malformation patients: Case series and a guideline

Recently, a new type of dental anomaly, a molar–incisor malformation or molar root– incisor malformation (MRIM), was recognized. The disease phenotype is now relatively well char-acterized; however, its etiology and disease-mechanism need to be elucidated. The affected teeth do not respond well to conventional treatment because of severe malformation and an unusual root structure. In this study, we present the treatment of MRIM cases with the extraction of severely aberrant permanent first molars (PFMs) and suggest that the PFM extractions are performed when it is clear that third molars will develop. The purpose of this report was primarily to present amend-ments to the guidelines for the treatment of patients with MRIM.