Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body

Sang Bong Lee; Hye Lan Kim; Hwan Jeong Jeong; Seok Tae Lim; Myung Hee Sohn; Dong Wook Kim

doi:10.1002/anie.201304026

Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body

Sang Bong Lee
, Hye Lan Kim
, Hwan Jeong Jeong
, Seok Tae Lim
, Myung Hee Sohn
, Dong Wook Kim^*

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Journal article › peer-review

149 Scopus citations

Abstract

Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.

Original language	English
Pages (from-to)	10549-10552
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	40
DOIs	https://doi.org/10.1002/anie.201304026
State	Published - 2013.09.27

Keywords

bioorthogonal reactions
mesoporous silica
molecular imaging
nanoparticles
radiopharmaceuticals

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Engineering - Chemical
Chemistry

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10.1002/anie.201304026

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title = "Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body",

abstract = "Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.",

keywords = "bioorthogonal reactions, mesoporous silica, molecular imaging, nanoparticles, radiopharmaceuticals",

author = "Lee, \{Sang Bong\} and Kim, \{Hye Lan\} and Jeong, \{Hwan Jeong\} and Lim, \{Seok Tae\} and Sohn, \{Myung Hee\} and Kim, \{Dong Wook\}",

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AU - Lee, Sang Bong

AU - Kim, Hye Lan

AU - Jeong, Hwan Jeong

AU - Lim, Seok Tae

AU - Sohn, Myung Hee

AU - Kim, Dong Wook

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.

AB - Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.

KW - bioorthogonal reactions

KW - mesoporous silica

KW - molecular imaging

KW - nanoparticles

KW - radiopharmaceuticals

UR - https://www.scopus.com/pages/publications/84884866696

U2 - 10.1002/anie.201304026

DO - 10.1002/anie.201304026

M3 - Journal article

C2 - 23956036

AN - SCOPUS:84884866696

SN - 1433-7851

VL - 52

SP - 10549

EP - 10552

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 40

ER -

Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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