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Molecular imaging of technetium-labeled galactosyl-methylated chitosan for liver-specific diagnosis

  • I. K. Park*
  • , H. J. Jeong
  • , E. M. Kim
  • , H. S. Bom
  • , T. Akaike
  • , C. S. Cho
  • *Corresponding author for this work
  • Seoul National University
  • Wonkwang University
  • Chonnam National University
  • Institute of Science Tokyo

Research output: Contribution to conferenceConference paperpeer-review

Abstract

99mTc-labeled galactosyl-methylated chitosan (GMC) were developed and characterized as liver-targeted in vivo molecular imaging carrier. GMC showed very high labeling efficiency of 99mTc stably for extended time (up to 3h). GMC showed enhanced hepatic contrast due to liver-specific uptake contrary to faint liver uptake of methylated chitosan (MC). Liver-targeted imaging of GMC indicated hepatic accumulation of GMC via specific interaction between galactose group of GMC and asialoglycoprotein receptors on the hepatocytes.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1640
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 2004.05.172004.05.21

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period04.05.1704.05.21

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