@inproceedings{d8ca0b165078476b8c8ad9c844c27414,
title = "Multi-step organic synthesis of four different molecular probes in digital microfluidic devices",
abstract = "Digital microfluidic devices are a versatile platform for batch chemical synthesis at the microscale. They are compatible with a wide range of chemicals and temperatures, their open structure facilitates evaporations that enable solvent exchange processes which are critical in multi-step reaction schemes, and the use of small volumes permits optimizations that can lead to reduced synthesis time. These properties and advantages are especially suitable for the multi-step synthesis of molecular imaging tracers for positron emission tomography (PET). We demonstrate the reliable multi-step synthesis of four compounds labeled with the short-lived radioisotope fluorine-18.",
keywords = "Digital microfluidics, Electrowetting on dielectric (EWOD), Multi-step synthesis, Organic chemistry, Radiosynthesis",
author = "Kim, \{Hee Kwon\} and Supin Chen and Javed, \{Muhammad Rashed\} and Jack Lei and Kim, \{Chang Jin\} and Keng, \{Pei Yuin\} and \{Van Dam\}, \{R. Michael\}",
year = "2012",
language = "English",
isbn = "9780979806452",
series = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
publisher = "Chemical and Biological Microsystems Society",
pages = "617--619",
booktitle = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
note = "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 ; Conference date: 28-10-2012 Through 01-11-2012",
}