Neuraminidase inhibitors from the culture broth of Phellinus linteus

Ji Hee Yeom; In Kyoung Lee; Dae Won Ki; Myeong Seok Lee; Soon Ja Seok; Bong Sik Yun

doi:10.5941/MYCO.2012.40.2.142

Neuraminidase inhibitors from the culture broth of Phellinus linteus

Ji Hee Yeom
, In Kyoung Lee
, Dae Won Ki
, Myeong Seok Lee
, Soon Ja Seok
, Bong Sik Yun^*

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University
Rural Development Administration

Research output: Contribution to journal › Comment/debate

15 Scopus citations

Abstract

During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC₅₀ values of 13.1 and 0.03μM, respectively.

Original language	English
Pages (from-to)	142-144
Number of pages	3
Journal	Mycobiology
Volume	40
Issue number	2
DOIs	https://doi.org/10.5941/MYCO.2012.40.2.142
State	Published - 2012.06

Keywords

Hispidin
Hypholomine B
Neuraminidase inhibitor
Phellinus linteus

Quacquarelli Symonds(QS) Subject Topics

Medicine
Biological Sciences

Access to Document

10.5941/MYCO.2012.40.2.142

Cite this

@article{6d4ddb21266d4750a0c02dcf50654d4a,

title = "Neuraminidase inhibitors from the culture broth of Phellinus linteus",

abstract = "During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC50 values of 13.1 and 0.03μM, respectively.",

keywords = "Hispidin, Hypholomine B, Neuraminidase inhibitor, Phellinus linteus",

author = "Yeom, \{Ji Hee\} and Lee, \{In Kyoung\} and Ki, \{Dae Won\} and Lee, \{Myeong Seok\} and Seok, \{Soon Ja\} and Yun, \{Bong Sik\}",

year = "2012",

month = jun,

doi = "10.5941/MYCO.2012.40.2.142",

language = "English",

volume = "40",

pages = "142--144",

journal = "Mycobiology",

issn = "1229-8093",

number = "2",

}

TY - JOUR

T1 - Neuraminidase inhibitors from the culture broth of Phellinus linteus

AU - Yeom, Ji Hee

AU - Lee, In Kyoung

AU - Ki, Dae Won

AU - Lee, Myeong Seok

AU - Seok, Soon Ja

AU - Yun, Bong Sik

PY - 2012/6

Y1 - 2012/6

N2 - During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC50 values of 13.1 and 0.03μM, respectively.

AB - During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC50 values of 13.1 and 0.03μM, respectively.

KW - Hispidin

KW - Hypholomine B

KW - Neuraminidase inhibitor

KW - Phellinus linteus

UR - https://www.scopus.com/pages/publications/84868218415

U2 - 10.5941/MYCO.2012.40.2.142

DO - 10.5941/MYCO.2012.40.2.142

M3 - Comment/debate

AN - SCOPUS:84868218415

SN - 1229-8093

VL - 40

SP - 142

EP - 144

JO - Mycobiology

JF - Mycobiology

IS - 2

ER -

Neuraminidase inhibitors from the culture broth of Phellinus linteus

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Cite this