Neuraminidase inhibitors from the fruiting body of Phellinus igniarius

Ji Yul Kim; Dae Won Kim; Byung Soon Hwang; E. Eum Woo; Yoon Ju Lee; Kyeong Woon Jeong; In Kyoung Lee; Bong Sik Yun

doi:10.5941/MYCO.2016.44.2.117

Neuraminidase inhibitors from the fruiting body of Phellinus igniarius

Ji Yul Kim
, Dae Won Kim
, Byung Soon Hwang
, E. Eum Woo
, Yoon Ju Lee
, Kyeong Woon Jeong
, In Kyoung Lee
, Bong Sik Yun^*

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

10 Scopus citations

Abstract

During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (1H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC₅₀ values in the range of 0.7~8.1 μM.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	Mycobiology
Volume	44
Issue number	2
DOIs	https://doi.org/10.5941/MYCO.2016.44.2.117
State	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Neuraminidase inhibitor
Phelligridin E
Phelligridin G
Phellinus igniarius

Quacquarelli Symonds(QS) Subject Topics

Medicine
Biological Sciences

Access to Document

10.5941/MYCO.2016.44.2.117

Cite this

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title = "Neuraminidase inhibitors from the fruiting body of Phellinus igniarius",

abstract = "During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (1H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7\textasciitilde{}8.1 μM.",

keywords = "Neuraminidase inhibitor, Phelligridin E, Phelligridin G, Phellinus igniarius",

author = "Kim, \{Ji Yul\} and Kim, \{Dae Won\} and Hwang, \{Byung Soon\} and Woo, \{E. Eum\} and Lee, \{Yoon Ju\} and Jeong, \{Kyeong Woon\} and Lee, \{In Kyoung\} and Yun, \{Bong Sik\}",

note = "Publisher Copyright: {\textcopyright} The Korean Society of Mycology.",

year = "2016",

doi = "10.5941/MYCO.2016.44.2.117",

language = "English",

volume = "44",

pages = "117--120",

journal = "Mycobiology",

issn = "1229-8093",

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}

TY - JOUR

T1 - Neuraminidase inhibitors from the fruiting body of Phellinus igniarius

AU - Kim, Ji Yul

AU - Kim, Dae Won

AU - Hwang, Byung Soon

AU - Woo, E. Eum

AU - Lee, Yoon Ju

AU - Jeong, Kyeong Woon

AU - Lee, In Kyoung

AU - Yun, Bong Sik

PY - 2016

Y1 - 2016

N2 - During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (1H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1 μM.

AB - During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (1H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1 μM.

KW - Neuraminidase inhibitor

KW - Phelligridin E

KW - Phelligridin G

KW - Phellinus igniarius

UR - https://www.scopus.com/pages/publications/84979950254

U2 - 10.5941/MYCO.2016.44.2.117

DO - 10.5941/MYCO.2016.44.2.117

M3 - Journal article

AN - SCOPUS:84979950254

SN - 1229-8093

VL - 44

SP - 117

EP - 120

JO - Mycobiology

JF - Mycobiology

IS - 2

ER -

Neuraminidase inhibitors from the fruiting body of Phellinus igniarius

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

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