Neuroprotective activity of P-terphenyl leucomentins from the mushroom paxillu panuoides

In Kyoung Lee; Bong Sik Yun; Jong Pyung Kim; In Ja Ryoo; Young Ho Kim; Ick Dong Yoo

doi:10.1271/bbb.67.1813

Neuroprotective activity of P-terphenyl leucomentins from the mushroom paxillu panuoides

In Kyoung Lee
, Bong Sik Yun
, Jong Pyung Kim
, In Ja Ryoo
, Young Ho Kim
, Ick Dong Yoo^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Research Institute of Bioscience and Biotechnology
Chungnam National University

Research output: Contribution to journal › Journal article › peer-review

32 Scopus citations

Abstract

The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H₂O₂ neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H₂O₂, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.

Original language	English
Pages (from-to)	1813-1816
Number of pages	4
Journal	Bioscience, Biotechnology, and Biochemistry
Volume	67
Issue number	8
DOIs	https://doi.org/10.1271/bbb.67.1813
State	Published - 2003.01.1

Keywords

Glutamate neurotoxicity
Iron chelator
Leu-comentins
Mushroom
Paxillus panuoides

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title = "Neuroprotective activity of P-terphenyl leucomentins from the mushroom paxillu panuoides",

abstract = "The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.",

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year = "2003",

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doi = "10.1271/bbb.67.1813",

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T1 - Neuroprotective activity of P-terphenyl leucomentins from the mushroom paxillu panuoides

AU - Lee, In Kyoung

AU - Yun, Bong Sik

AU - Kim, Jong Pyung

AU - Ryoo, In Ja

AU - Kim, Young Ho

AU - Yoo, Ick Dong

PY - 2003/1/1

Y1 - 2003/1/1

N2 - The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.

AB - The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.

KW - Glutamate neurotoxicity

KW - Iron chelator

KW - Leu-comentins

KW - Mushroom

KW - Paxillus panuoides

UR - https://www.scopus.com/pages/publications/2442603741

U2 - 10.1271/bbb.67.1813

DO - 10.1271/bbb.67.1813

M3 - Journal article

C2 - 12951520

AN - SCOPUS:2442603741

SN - 0916-8451

VL - 67

SP - 1813

EP - 1816

JO - Bioscience, Biotechnology, and Biochemistry

JF - Bioscience, Biotechnology, and Biochemistry

IS - 8

ER -

Neuroprotective activity of P-terphenyl leucomentins from the mushroom paxillu panuoides

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Keywords

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