New dimeric 5-hydroxy-2-hexenoic acid isolated from culture broth of Clonostachys rogersoniana

A new dimeric 5-hydroxy-2-hexenoic acid, clonohexenoic acid (1), a known 14-membered macrolide, acremodiol B (2), and two known benzochromenone derivatives, alternariol (3) and 2-hydroxyalternariol (4), were isolated from a culture broth of Clonostachys rogersoniana. The structures of these isolated compounds were determined using spectroscopic methods. Antimicrobial and cytotoxic activities of these compounds were then assessed. Compounds 1‒4 exhibited antimicrobial activities against Bacillus subtilis and Propionibacterium acnes. In addition, compounds 3 and 4 showed antibacterial activities against B. cereus and cytotoxic activities against three human cancer cell lines, A549, HCT-116, and Mia Paca-2.