New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.

Won Gon Kim; In Ja Ryoo; Bong Sik Yun; Kazuo Shin-ya; Haruo Seto; Ick Dong Yoo

doi:10.7164/antibiotics.50.715

New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.

Won Gon Kim
, In Ja Ryoo
, Bong Sik Yun
, Kazuo Shin-ya
, Haruo Seto
, Ick Dong Yoo^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Institute of Science and Technology
The University of Tokyo

Research output: Contribution to journal › Journal article › peer-review

33 Scopus citations

Abstract

Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC₅₀ values of 0.34 and 0.33 μM, respectively.

Original language	English
Pages (from-to)	715-721
Number of pages	7
Journal	Journal of Antibiotics
Volume	50
Issue number	9
DOIs	https://doi.org/10.7164/antibiotics.50.715
State	Published - 1997.09

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10.7164/antibiotics.50.715

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title = "New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.",

abstract = "Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 μM, respectively.",

author = "Kim, \{Won Gon\} and Ryoo, \{In Ja\} and Yun, \{Bong Sik\} and Kazuo Shin-ya and Haruo Seto and Yoo, \{Ick Dong\}",

year = "1997",

month = sep,

doi = "10.7164/antibiotics.50.715",

language = "English",

volume = "50",

pages = "715--721",

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TY - JOUR

T1 - New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.

AU - Kim, Won Gon

AU - Ryoo, In Ja

AU - Yun, Bong Sik

AU - Shin-ya, Kazuo

AU - Seto, Haruo

AU - Yoo, Ick Dong

PY - 1997/9

Y1 - 1997/9

N2 - Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 μM, respectively.

AB - Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 μM, respectively.

UR - https://www.scopus.com/pages/publications/0030831830

U2 - 10.7164/antibiotics.50.715

DO - 10.7164/antibiotics.50.715

M3 - Journal article

C2 - 9360614

AN - SCOPUS:0030831830

SN - 0021-8820

VL - 50

SP - 715

EP - 721

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 9

ER -

New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.

Abstract

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