New glabretal triterpenes from the immature fruits of poncirus trifoliata and their selective cytotoxicity

Ae Ran Choi; In Kyoung Lee; E. Eum Woo; Jin Won Kwon; Bong Sik Yun; Hae Ryong Park

doi:10.1248/cpb.c15-00465

New glabretal triterpenes from the immature fruits of poncirus trifoliata and their selective cytotoxicity

Ae Ran Choi
, In Kyoung Lee
, E. Eum Woo
, Jin Won Kwon
, Bong Sik Yun
, Hae Ryong Park^*

^*Corresponding author for this work

Environmental Biotechnology

Kyungnam University
Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

7 Scopus citations

Abstract

Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.

Original language	English
Pages (from-to)	1065-1069
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	63
Issue number	12
DOIs	https://doi.org/10.1248/cpb.c15-00465
State	Published - 2015.12.1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Glabretal triterpene
Pancastatin
Poncirus trifoliata
Selective cytotoxicity

Quacquarelli Symonds(QS) Subject Topics

Pharmacy & Pharmacology
Chemistry

Access to Document

10.1248/cpb.c15-00465

Cite this

@article{156863bcb58c4248acfb51a161498f26,

title = "New glabretal triterpenes from the immature fruits of poncirus trifoliata and their selective cytotoxicity",

abstract = "Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.",

keywords = "Glabretal triterpene, Pancastatin, Poncirus trifoliata, Selective cytotoxicity",

author = "Choi, \{Ae Ran\} and Lee, \{In Kyoung\} and Woo, \{E. Eum\} and Kwon, \{Jin Won\} and Yun, \{Bong Sik\} and Park, \{Hae Ryong\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Pharmaceutical Society of Japan.",

year = "2015",

month = dec,

day = "1",

doi = "10.1248/cpb.c15-00465",

language = "English",

volume = "63",

pages = "1065--1069",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

number = "12",

}

TY - JOUR

T1 - New glabretal triterpenes from the immature fruits of poncirus trifoliata and their selective cytotoxicity

AU - Choi, Ae Ran

AU - Lee, In Kyoung

AU - Woo, E. Eum

AU - Kwon, Jin Won

AU - Yun, Bong Sik

AU - Park, Hae Ryong

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.

AB - Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.

KW - Glabretal triterpene

KW - Pancastatin

KW - Poncirus trifoliata

KW - Selective cytotoxicity

UR - https://www.scopus.com/pages/publications/84955494192

U2 - 10.1248/cpb.c15-00465

DO - 10.1248/cpb.c15-00465

M3 - Journal article

C2 - 26633028

AN - SCOPUS:84955494192

SN - 0009-2363

VL - 63

SP - 1065

EP - 1069

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 12

ER -

New glabretal triterpenes from the immature fruits of poncirus trifoliata and their selective cytotoxicity

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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