New guaiane sesquiterpenes from the fruits of Torilis japonica

In Kyoung Lee; Jeong Hyung Lee; Eui Il Hwang; Bong Sik Yun

doi:10.1248/cpb.56.1483

New guaiane sesquiterpenes from the fruits of Torilis japonica

In Kyoung Lee
, Jeong Hyung Lee
, Eui Il Hwang
, Bong Sik Yun^*

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University
Kangwon National University
KT and G Central Research Institute

Research output: Contribution to journal › Journal article › peer-review

17 Scopus citations

Abstract

Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4- guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.

Original language	English
Pages (from-to)	1483-1485
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	10
DOIs	https://doi.org/10.1248/cpb.56.1483
State	Published - 2008.10

Keywords

Guaiane sesquiterpenoid
Nitric oxide production inhibitor
Torilis japonica
Umbelliferae

Quacquarelli Symonds(QS) Subject Topics

Pharmacy & Pharmacology
Chemistry

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10.1248/cpb.56.1483

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title = "New guaiane sesquiterpenes from the fruits of Torilis japonica",

abstract = "Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4- guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.",

keywords = "Guaiane sesquiterpenoid, Nitric oxide production inhibitor, Torilis japonica, Umbelliferae",

author = "Lee, \{In Kyoung\} and Lee, \{Jeong Hyung\} and Hwang, \{Eui Il\} and Yun, \{Bong Sik\}",

year = "2008",

month = oct,

doi = "10.1248/cpb.56.1483",

language = "English",

volume = "56",

pages = "1483--1485",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

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TY - JOUR

T1 - New guaiane sesquiterpenes from the fruits of Torilis japonica

AU - Lee, In Kyoung

AU - Lee, Jeong Hyung

AU - Hwang, Eui Il

AU - Yun, Bong Sik

PY - 2008/10

Y1 - 2008/10

N2 - Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4- guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.

AB - Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4- guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.

KW - Guaiane sesquiterpenoid

KW - Nitric oxide production inhibitor

KW - Torilis japonica

KW - Umbelliferae

UR - https://www.scopus.com/pages/publications/54349118382

U2 - 10.1248/cpb.56.1483

DO - 10.1248/cpb.56.1483

M3 - Journal article

C2 - 18827397

AN - SCOPUS:54349118382

SN - 0009-2363

VL - 56

SP - 1483

EP - 1485

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 10

ER -

New guaiane sesquiterpenes from the fruits of Torilis japonica

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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