New macrolactone secondary metabolites produced from a strain of cytophaga sp.

Methicillin-resistant Staphylococcus aureus (MRSA) is the major cause of nosocomial infections which have become a serious clinical problem during the past decade. Glycopeptides such as vancomycin and teicoplanin are currently the agents of choice for the treatment of MRSA infection. However, they suffer from a number of drawbacks, including a relative high failure rate, poor tissue penetration, serious adverse effects and unpredictable synergy with other antimicrobial agents. The H-21/C-1 HMBC correlation provides strong evidence on the existence of macrocyclic lactone ring. The production culture medium (20 liters) was chosen among the three media, which was cultured on a jar fermentor for 4 days at 30° C with an air flow of 2-3 liters per minute and agitation rate of 175 rpm.