No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

Yong Chan Kim; Sae Young Won; Byung Hoon Jeong

doi:10.1007/s13273-022-00318-x

No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

Yong Chan Kim
, Sae Young Won
, Byung Hoon Jeong^*

^*Corresponding author for this work

Korea Zoonosis Research Institute at Jeonbuk National University

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

Abstract

Background: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice. Objective: Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu. Results: We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu. Conclusions: To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.

Original language	English
Pages (from-to)	799-803
Number of pages	5
Journal	Molecular and Cellular Toxicology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1007/s13273-022-00318-x
State	Published - 2023.10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

H1N1
Influenza
Pandemic
Prion disease
PRNP
SNP
Susceptibility

Quacquarelli Symonds(QS) Subject Topics

Environmental Sciences
Medicine
Pharmacy & Pharmacology

Access to Document

10.1007/s13273-022-00318-x

Cite this

@article{0c5a03145c1f43dfa6290cd725979353,

title = "No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu",

abstract = "Background: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice. Objective: Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu. Results: We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu. Conclusions: To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.",

keywords = "H1N1, Influenza, Pandemic, Prion disease, PRNP, SNP, Susceptibility",

author = "Kim, \{Yong Chan\} and Won, \{Sae Young\} and Jeong, \{Byung Hoon\}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s) under exclusive licence to The Korean Society of Toxicogenomics and Toxicoproteomics.",

year = "2023",

month = oct,

doi = "10.1007/s13273-022-00318-x",

language = "English",

volume = "19",

pages = "799--803",

journal = "Molecular and Cellular Toxicology",

issn = "1738-642X",

number = "4",

}

TY - JOUR

T1 - No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

AU - Kim, Yong Chan

AU - Won, Sae Young

AU - Jeong, Byung Hoon

PY - 2023/10

Y1 - 2023/10

N2 - Background: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice. Objective: Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu. Results: We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu. Conclusions: To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.

AB - Background: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice. Objective: Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu. Results: We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu. Conclusions: To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.

KW - H1N1

KW - Influenza

KW - Pandemic

KW - Prion disease

KW - PRNP

KW - SNP

KW - Susceptibility

UR - https://www.scopus.com/pages/publications/85141697651

U2 - 10.1007/s13273-022-00318-x

DO - 10.1007/s13273-022-00318-x

M3 - Journal article

AN - SCOPUS:85141697651

SN - 1738-642X

VL - 19

SP - 799

EP - 803

JO - Molecular and Cellular Toxicology

JF - Molecular and Cellular Toxicology

IS - 4

ER -

No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Researchers' Work from Jeonbuk National University Focuses on Influenza A Virus [No Association of Prion Protein Gene (Prnp) Polymorphisms With Susceptibility To the Pandemic 2009 Swine Flu]

Cite this

No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Press/Media

Researchers' Work from Jeonbuk National University Focuses on Influenza A Virus [No Association of Prion Protein Gene (Prnp) Polymorphisms With Susceptibility To the Pandemic 2009 Swine Flu]

Cite this