One-pot synthesis of carbamates and thiocarbamates from Boc-protected amines

Research output: Contribution to journalJournal articlepeer-review

Abstract

A highly efficient one-pot procedure for the synthesis of carbamates and thiocarbamates has been described. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, the isocyanate intermediates were generated in situ for further reactions with alcohols and thiols to afford the desired carbamates and thiocarbamates in high yields.

Original languageEnglish
Pages (from-to)4890-4892
Number of pages3
JournalTetrahedron Letters
Volume57
Issue number44
DOIs
StatePublished - 2016

Keywords

  • Carbamates
  • Isocyanate intermediates
  • One-pot synthesis
  • Thiocarbamates

Quacquarelli Symonds(QS) Subject Topics

  • Engineering - Petroleum
  • Pharmacy & Pharmacology
  • Chemistry
  • Biological Sciences

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