Abstract
Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.
| Original language | English |
|---|---|
| Pages (from-to) | 11021-11024 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 42 |
| DOIs | |
| State | Published - 2013.10.11 |
Keywords
- GPCR
- homology modeling
- olfactory receptor
- protein structures
- receptors
Quacquarelli Symonds(QS) Subject Topics
- Engineering - Petroleum
- Engineering - Chemical
- Chemistry
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