Opsin, a structural model for olfactory receptors?

  • Jung Hee Park
  • , Takefumi Morizumi
  • , Yafang Li
  • , Joo Eun Hong
  • , Emil F. Pai
  • , Klaus Peter Hofmann
  • , Hui Woog Choe
  • , Oliver P. Ernst

Research output: Contribution to journalJournal articlepeer-review

Abstract

Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.

Original languageEnglish
Pages (from-to)11021-11024
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number42
DOIs
StatePublished - 2013.10.11

Keywords

  • GPCR
  • homology modeling
  • olfactory receptor
  • protein structures
  • receptors

Quacquarelli Symonds(QS) Subject Topics

  • Engineering - Petroleum
  • Engineering - Chemical
  • Chemistry

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