Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

Ji Woong Jang; Jeong Ho Yun; Kwang Il Lee; Ju Woong Jang; Ui Won Jung; Chang Sung Kim; Seong Ho Choi; Kyoo Sung Cho

doi:10.1016/j.tripleo.2011.04.013

Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

Ji Woong Jang
, Jeong Ho Yun
, Kwang Il Lee
, Ju Woong Jang
, Ui Won Jung
, Chang Sung Kim
, Seong Ho Choi
, Kyoo Sung Cho^*

^*Corresponding author for this work

Department of Dentistry

Yonsei University
Inha University
Institute of Bio Material and Medical Engineering

Research output: Contribution to journal › Journal article › peer-review

70 Scopus citations

Abstract

Objective. The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. Study Design. Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. Results. The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. Conclusions. rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.

Original language	English
Pages (from-to)	480-487
Number of pages	8
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	113
Issue number	4
DOIs	https://doi.org/10.1016/j.tripleo.2011.04.013
State	Published - 2012.04

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@article{d3559dcb3b844f77892fc47b42be96bc,

title = "Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats",

abstract = "Objective. The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. Study Design. Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. Results. The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. Conclusions. rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.",

author = "Jang, \{Ji Woong\} and Yun, \{Jeong Ho\} and Lee, \{Kwang Il\} and Jang, \{Ju Woong\} and Jung, \{Ui Won\} and Kim, \{Chang Sung\} and Choi, \{Seong Ho\} and Cho, \{Kyoo Sung\}",

year = "2012",

month = apr,

doi = "10.1016/j.tripleo.2011.04.013",

language = "English",

volume = "113",

pages = "480--487",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

issn = "2212-4403",

number = "4",

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TY - JOUR

T1 - Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

AU - Jang, Ji Woong

AU - Yun, Jeong Ho

AU - Lee, Kwang Il

AU - Jang, Ju Woong

AU - Jung, Ui Won

AU - Kim, Chang Sung

AU - Choi, Seong Ho

AU - Cho, Kyoo Sung

PY - 2012/4

Y1 - 2012/4

N2 - Objective. The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. Study Design. Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. Results. The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. Conclusions. rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.

AB - Objective. The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. Study Design. Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. Results. The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. Conclusions. rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.

UR - https://www.scopus.com/pages/publications/84862581854

U2 - 10.1016/j.tripleo.2011.04.013

DO - 10.1016/j.tripleo.2011.04.013

M3 - Journal article

C2 - 22676929

AN - SCOPUS:84862581854

SN - 2212-4403

VL - 113

SP - 480

EP - 487

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

IS - 4

ER -

Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

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