Oxidative stress and metal carcinogenesis

Jeong Chae Lee; Young Ok Son; Poyil Pratheeshkumar; Xianglin Shi

doi:10.1016/j.freeradbiomed.2012.06.002

Oxidative stress and metal carcinogenesis

Jeong Chae Lee
, Young Ok Son
, Poyil Pratheeshkumar
, Xianglin Shi^*

^*Corresponding author for this work

Department of Dentistry

University of Kentucky

Research output: Contribution to journal › Review article › peer-review

258 Scopus citations

Abstract

Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.

Original language	English
Pages (from-to)	742-757
Number of pages	16
Journal	Free Radical Biology and Medicine
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/j.freeradbiomed.2012.06.002
State	Published - 2012.08.15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carcinogenesis
Metals
Reactive oxygen species
Signal transduction

Quacquarelli Symonds(QS) Subject Topics

Anatomy & Physiology
Biological Sciences

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10.1016/j.freeradbiomed.2012.06.002

Cite this

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title = "Oxidative stress and metal carcinogenesis",

abstract = "Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.",

keywords = "Carcinogenesis, Metals, Reactive oxygen species, Signal transduction",

author = "Lee, \{Jeong Chae\} and Son, \{Young Ok\} and Poyil Pratheeshkumar and Xianglin Shi",

year = "2012",

month = aug,

day = "15",

doi = "10.1016/j.freeradbiomed.2012.06.002",

language = "English",

volume = "53",

pages = "742--757",

journal = "Free Radical Biology and Medicine",

issn = "0891-5849",

number = "4",

}

TY - JOUR

T1 - Oxidative stress and metal carcinogenesis

AU - Lee, Jeong Chae

AU - Son, Young Ok

AU - Pratheeshkumar, Poyil

AU - Shi, Xianglin

PY - 2012/8/15

Y1 - 2012/8/15

N2 - Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.

AB - Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.

KW - Carcinogenesis

KW - Metals

KW - Reactive oxygen species

KW - Signal transduction

UR - https://www.scopus.com/pages/publications/84864408817

U2 - 10.1016/j.freeradbiomed.2012.06.002

DO - 10.1016/j.freeradbiomed.2012.06.002

M3 - Review article

C2 - 22705365

AN - SCOPUS:84864408817

SN - 0891-5849

VL - 53

SP - 742

EP - 757

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

IS - 4

ER -

Oxidative stress and metal carcinogenesis

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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