Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease

Yuanqiang Ma; Gyurim Lee; Su Young Heo; Yoon Seok Roh

doi:10.3390/antiox11010091

Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease

Yuanqiang Ma
, Gyurim Lee
, Su Young Heo^*
, Yoon Seok Roh^*

^*Corresponding author for this work

Department of Veterinary Medicine

Chungbuk National University

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.

Original language	English
Article number	91
Journal	Antioxidants
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/antiox11010091
State	Published - 2022.01

Keywords

Antioxidants
ER stress
Fibrosis
Hepatocytes
HSC
Inflammation
Kupffer cells
Lipid metabolism
Mitochondria
NAFLD
Oxidative stress
Peroxisome
ROS

Quacquarelli Symonds(QS) Subject Topics

Agriculture & Forestry
Anatomy & Physiology
Biological Sciences

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10.3390/antiox11010091

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@article{3f41e8cb332f437790ef2478917bf663,

title = "Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease",

abstract = "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.",

keywords = "Antioxidants, ER stress, Fibrosis, Hepatocytes, HSC, Inflammation, Kupffer cells, Lipid metabolism, Mitochondria, NAFLD, Oxidative stress, Peroxisome, ROS",

author = "Yuanqiang Ma and Gyurim Lee and Heo, \{Su Young\} and Roh, \{Yoon Seok\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

doi = "10.3390/antiox11010091",

language = "English",

volume = "11",

journal = "Antioxidants",

issn = "2076-3921",

number = "1",

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TY - JOUR

T1 - Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease

AU - Ma, Yuanqiang

AU - Lee, Gyurim

AU - Heo, Su Young

AU - Roh, Yoon Seok

PY - 2022/1

Y1 - 2022/1

N2 - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.

AB - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.

KW - Antioxidants

KW - ER stress

KW - Fibrosis

KW - Hepatocytes

KW - HSC

KW - Inflammation

KW - Kupffer cells

KW - Lipid metabolism

KW - Mitochondria

KW - NAFLD

KW - Oxidative stress

KW - Peroxisome

KW - ROS

UR - https://www.scopus.com/pages/publications/85121866839

U2 - 10.3390/antiox11010091

DO - 10.3390/antiox11010091

M3 - Review article

AN - SCOPUS:85121866839

SN - 2076-3921

VL - 11

JO - Antioxidants

JF - Antioxidants

IS - 1

M1 - 91

ER -

Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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