p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea

Dae Cheol Choi; Dae Won Ki; Ji Yul Kim; In Kyoung Lee; Bong Sik Yun

doi:10.1038/s41429-022-00579-7

p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea

Dae Cheol Choi
, Dae Won Ki
, Ji Yul Kim
, In Kyoung Lee
, Bong Sik Yun^*

^*Corresponding author for this work

Environmental Biotechnology

Jeonbuk National University
National Marine Biodiversity Institute of Korea

Research output: Contribution to journal › Journal article › peer-review

3 Scopus citations

Abstract

A new p-terphenyl derivative, hydroxystrepantibin D (1), was isolated along with two known p-terphenyls (2 and 3) from the culture broth of Phlebiopsis castanea. These compounds were isolated using silica gel column chromatography, reversed-phase medium-pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined based on spectroscopic methods. These compounds exhibited free radical scavenging activities with IC₅₀ values in the range from 22.2 to 158.4 μM against 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical and in the range from 161.1 to 356.1 μM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.

Original language	English
Pages (from-to)	52-55
Number of pages	4
Journal	Journal of Antibiotics
Volume	76
Issue number	1
DOIs	https://doi.org/10.1038/s41429-022-00579-7
State	Published - 2023.01

Quacquarelli Symonds(QS) Subject Topics

Pharmacy & Pharmacology

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title = "p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea",

abstract = "A new p-terphenyl derivative, hydroxystrepantibin D (1), was isolated along with two known p-terphenyls (2 and 3) from the culture broth of Phlebiopsis castanea. These compounds were isolated using silica gel column chromatography, reversed-phase medium-pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined based on spectroscopic methods. These compounds exhibited free radical scavenging activities with IC50 values in the range from 22.2 to 158.4 μM against 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical and in the range from 161.1 to 356.1 μM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.",

author = "Choi, \{Dae Cheol\} and Ki, \{Dae Won\} and Kim, \{Ji Yul\} and Lee, \{In Kyoung\} and Yun, \{Bong Sik\}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.",

year = "2023",

month = jan,

doi = "10.1038/s41429-022-00579-7",

language = "English",

volume = "76",

pages = "52--55",

journal = "Journal of Antibiotics",

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TY - JOUR

T1 - p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea

AU - Choi, Dae Cheol

AU - Ki, Dae Won

AU - Kim, Ji Yul

AU - Lee, In Kyoung

AU - Yun, Bong Sik

PY - 2023/1

Y1 - 2023/1

N2 - A new p-terphenyl derivative, hydroxystrepantibin D (1), was isolated along with two known p-terphenyls (2 and 3) from the culture broth of Phlebiopsis castanea. These compounds were isolated using silica gel column chromatography, reversed-phase medium-pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined based on spectroscopic methods. These compounds exhibited free radical scavenging activities with IC50 values in the range from 22.2 to 158.4 μM against 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical and in the range from 161.1 to 356.1 μM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.

AB - A new p-terphenyl derivative, hydroxystrepantibin D (1), was isolated along with two known p-terphenyls (2 and 3) from the culture broth of Phlebiopsis castanea. These compounds were isolated using silica gel column chromatography, reversed-phase medium-pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined based on spectroscopic methods. These compounds exhibited free radical scavenging activities with IC50 values in the range from 22.2 to 158.4 μM against 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical and in the range from 161.1 to 356.1 μM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.

UR - https://www.scopus.com/pages/publications/85141978988

U2 - 10.1038/s41429-022-00579-7

DO - 10.1038/s41429-022-00579-7

M3 - Journal article

C2 - 36380241

AN - SCOPUS:85141978988

SN - 0021-8820

VL - 76

SP - 52

EP - 55

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 1

ER -

p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea

Abstract

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