Palladium-catalyzed decarboxylative aminocarbonylation with alkynoic acid and tertiary amine for the synthesis of alkynyl amide

Muhammad Aliyu Idris; Myungjin Kim; Jeung Gon Kim; Sunwoo Lee

doi:10.1016/j.tet.2019.04.030

Palladium-catalyzed decarboxylative aminocarbonylation with alkynoic acid and tertiary amine for the synthesis of alkynyl amide

Muhammad Aliyu Idris
, Myungjin Kim
, Jeung Gon Kim
, Sunwoo Lee^*

^*Corresponding author for this work

Department of Chemistry

Chonnam National University

Research output: Contribution to journal › Journal article › peer-review

15 Scopus citations

Abstract

We developed a method for the synthesis of alkynyl amides via the carbonylation of alkynoic acids and C-N activation of tertiary amines. The reaction of alkynoic acid and tertiary amine with carbon monoxide using a palladium catalyst in the presence of oxygen, KI, and K₃PO₄, gave the desired alkynyl amides in good yields.

Original language	English
Pages (from-to)	4130-4137
Number of pages	8
Journal	Tetrahedron
Volume	75
Issue number	31
DOIs	https://doi.org/10.1016/j.tet.2019.04.030
State	Published - 2019.08.2

Keywords

Alkynyl amide
Carbonylation
Decarboxylative coupling
Propiolic acids
Tertiary amine

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Pharmacy & Pharmacology
Chemistry
Biological Sciences

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10.1016/j.tet.2019.04.030

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title = "Palladium-catalyzed decarboxylative aminocarbonylation with alkynoic acid and tertiary amine for the synthesis of alkynyl amide",

abstract = "We developed a method for the synthesis of alkynyl amides via the carbonylation of alkynoic acids and C-N activation of tertiary amines. The reaction of alkynoic acid and tertiary amine with carbon monoxide using a palladium catalyst in the presence of oxygen, KI, and K3PO4, gave the desired alkynyl amides in good yields.",

keywords = "Alkynyl amide, Carbonylation, Decarboxylative coupling, Propiolic acids, Tertiary amine",

author = "Idris, \{Muhammad Aliyu\} and Myungjin Kim and Kim, \{Jeung Gon\} and Sunwoo Lee",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = aug,

day = "2",

doi = "10.1016/j.tet.2019.04.030",

language = "English",

volume = "75",

pages = "4130--4137",

journal = "Tetrahedron",

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TY - JOUR

T1 - Palladium-catalyzed decarboxylative aminocarbonylation with alkynoic acid and tertiary amine for the synthesis of alkynyl amide

AU - Idris, Muhammad Aliyu

AU - Kim, Myungjin

AU - Kim, Jeung Gon

AU - Lee, Sunwoo

PY - 2019/8/2

Y1 - 2019/8/2

N2 - We developed a method for the synthesis of alkynyl amides via the carbonylation of alkynoic acids and C-N activation of tertiary amines. The reaction of alkynoic acid and tertiary amine with carbon monoxide using a palladium catalyst in the presence of oxygen, KI, and K3PO4, gave the desired alkynyl amides in good yields.

AB - We developed a method for the synthesis of alkynyl amides via the carbonylation of alkynoic acids and C-N activation of tertiary amines. The reaction of alkynoic acid and tertiary amine with carbon monoxide using a palladium catalyst in the presence of oxygen, KI, and K3PO4, gave the desired alkynyl amides in good yields.

KW - Alkynyl amide

KW - Carbonylation

KW - Decarboxylative coupling

KW - Propiolic acids

KW - Tertiary amine

UR - https://www.scopus.com/pages/publications/85064678061

U2 - 10.1016/j.tet.2019.04.030

DO - 10.1016/j.tet.2019.04.030

M3 - Journal article

AN - SCOPUS:85064678061

SN - 0040-4020

VL - 75

SP - 4130

EP - 4137

JO - Tetrahedron

JF - Tetrahedron

IS - 31

ER -

Palladium-catalyzed decarboxylative aminocarbonylation with alkynoic acid and tertiary amine for the synthesis of alkynyl amide

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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