Pancreatic lipase inhibition by C-glycosidic flavones isolated from Eremochloa ophiuroides

Eun Mi Lee; Seung Sik Lee; Byung Yeoup Chung; Jae Young Cho; In Chul Lee; So Ra Ahn; Soo Jeung Jang; Tae Hoon Kim

doi:10.3390/molecules15118251

Pancreatic lipase inhibition by C-glycosidic flavones isolated from Eremochloa ophiuroides

Eun Mi Lee
, Seung Sik Lee
, Byung Yeoup Chung
, Jae Young Cho
, In Chul Lee
, So Ra Ahn
, Soo Jeung Jang
, Tae Hoon Kim

Department of Bioenvironmental Chemistry

Korea Atomic Energy Research Institute
U1 University
Daegu Haany University

Research output: Contribution to journal › Journal article › peer-review

92 Scopus citations

Abstract

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-Dboivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC₅₀ values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.

Original language	English
Pages (from-to)	8251-8259
Number of pages	9
Journal	Molecules
Volume	15
Issue number	11
DOIs	https://doi.org/10.3390/molecules15118251
State	Published - 2010.11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

C-glycosidic flavones
Eremochloa ophiuroides
Obesity
Pancreatic lipase

Quacquarelli Symonds(QS) Subject Topics

Medicine
Engineering - Petroleum
Pharmacy & Pharmacology
Chemistry

Access to Document

10.3390/molecules15118251

Cite this

@article{1c867e37996c4796828ea2413a0afb6e,

title = "Pancreatic lipase inhibition by C-glycosidic flavones isolated from Eremochloa ophiuroides",

abstract = "Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-Dboivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.",

keywords = "C-glycosidic flavones, Eremochloa ophiuroides, Obesity, Pancreatic lipase",

author = "Lee, \{Eun Mi\} and Lee, \{Seung Sik\} and Chung, \{Byung Yeoup\} and Cho, \{Jae Young\} and Lee, \{In Chul\} and Ahn, \{So Ra\} and Jang, \{Soo Jeung\} and Kim, \{Tae Hoon\}",

year = "2010",

month = nov,

doi = "10.3390/molecules15118251",

language = "English",

volume = "15",

pages = "8251--8259",

journal = "Molecules",

issn = "1420-3049",

number = "11",

}

TY - JOUR

T1 - Pancreatic lipase inhibition by C-glycosidic flavones isolated from Eremochloa ophiuroides

AU - Lee, Eun Mi

AU - Lee, Seung Sik

AU - Chung, Byung Yeoup

AU - Cho, Jae Young

AU - Lee, In Chul

AU - Ahn, So Ra

AU - Jang, Soo Jeung

AU - Kim, Tae Hoon

PY - 2010/11

Y1 - 2010/11

N2 - Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-Dboivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.

AB - Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-Dboivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC50 values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.

KW - C-glycosidic flavones

KW - Eremochloa ophiuroides

KW - Obesity

KW - Pancreatic lipase

UR - https://www.scopus.com/pages/publications/78649466429

U2 - 10.3390/molecules15118251

DO - 10.3390/molecules15118251

M3 - Journal article

C2 - 21081855

AN - SCOPUS:78649466429

SN - 1420-3049

VL - 15

SP - 8251

EP - 8259

JO - Molecules

JF - Molecules

IS - 11

ER -

Pancreatic lipase inhibition by C-glycosidic flavones isolated from Eremochloa ophiuroides

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

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