PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs

Hwa Pyeong Rim; Kyung Hyun Min; Hong Jae Lee; Seo Young Jeong; Sang Cheon Lee

doi:10.1002/anie.201101536

PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs

Hwa Pyeong Rim^*
, Kyung Hyun Min
, Hong Jae Lee
, Seo Young Jeong
, Sang Cheon Lee

^*Corresponding author for this work

Department of Pharmacy

Kyung Hee University

Research output: Contribution to journal › Journal article › peer-review

240 Scopus citations

Abstract

Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).

Original language	English
Pages (from-to)	8853-8857
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	38
DOIs	https://doi.org/10.1002/anie.201101536
State	Published - 2011.09.12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

drug delivery
host-guest systems
mesoporous materials
mineralization
nanoparticles

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10.1002/anie.201101536

Cite this

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title = "PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs",

abstract = "Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).",

keywords = "drug delivery, host-guest systems, mesoporous materials, mineralization, nanoparticles",

author = "Rim, \{Hwa Pyeong\} and Min, \{Kyung Hyun\} and Lee, \{Hong Jae\} and Jeong, \{Seo Young\} and Lee, \{Sang Cheon\}",

year = "2011",

month = sep,

day = "12",

doi = "10.1002/anie.201101536",

language = "English",

volume = "50",

pages = "8853--8857",

journal = "Angewandte Chemie - International Edition",

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T1 - PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs

AU - Rim, Hwa Pyeong

AU - Min, Kyung Hyun

AU - Lee, Hong Jae

AU - Jeong, Seo Young

AU - Lee, Sang Cheon

PY - 2011/9/12

Y1 - 2011/9/12

N2 - Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).

AB - Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).

KW - drug delivery

KW - host-guest systems

KW - mesoporous materials

KW - mineralization

KW - nanoparticles

UR - https://www.scopus.com/pages/publications/80052590095

U2 - 10.1002/anie.201101536

DO - 10.1002/anie.201101536

M3 - Journal article

C2 - 21826770

AN - SCOPUS:80052590095

SN - 1433-7851

VL - 50

SP - 8853

EP - 8857

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 38

ER -

PH-tunable calcium phosphate covered mesoporous silica nanocontainers for intracellular controlled release of guest drugs

Abstract

UN SDGs

Keywords

Access to Document

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